Magnesium L-threonate is a form of magnesium that has been studied for its potential benefits on brain health and cognitive function. It is known for its ability to cross the blood-brain barrier more effectively than other forms of magnesium, thus potentially increasing magnesium levels in the brain¹.

Some of the reported benefits include:

1. Cognitive Improvement: Magnesium L-threonate has been shown to enhance learning, memory, and overall cognitive function in both animal and human studies²³. In particular, a study among healthy Chinese adults found significant improvements in memory and cognition when supplemented with magnesium L-threonate³.

2. Neurological Protection: It has neuroprotective effects, which might be beneficial in conditions like Alzheimer's disease. This is thought to be mediated through its ability to modulate the microbiota-gut-brain axis and reduce oxidative stress and inflammation in animal models⁴⁵.

3. Memory and Pain Management: Magnesium L-threonate may also help prevent and restore memory deficits associated with chronic neuropathic pain by mechanisms involving inflammatory pathways⁶.

4. Effects Under Hypoxic Conditions: Studies in zebrafish models suggest magnesium L-threonate can help protect brain cells from hypoxic injury, which can support cognitive function⁷.

These studies indicate the potential of magnesium L-threonate in enhancing brain health and protecting against cognitive decline, but more research, especially in diverse human populations, is necessary to fully understand its effects and optimal use.

Footnotes

1. Chengxiang Zhang, "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults," PubMed Central, 2022. ↩

2. Chengxiang Zhang, "Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions," PubMed, 2022. ↩

3. Kemajl Bislimi, "Effects of Vitamin C and Magnesium L-threonate on Learning and Memory," PubMed Central, 2021. ↩ ↩²

4. Wang Liao, "Magnesium-L-threonate Treats Alzheimer’s Disease," Neural Regen Res, 2024. ↩

5. Ying Xiong, "Magnesium-L-threonate Exhibited Neuroprotective Effect," PubMed Central, 2022. ↩

6. Jun Wang, "Magnesium L-threonate Prevents Memory Deficits," PubMed, 2024. ↩

7. Young-Sung Kim, "Neuroprotective Effects of Magnesium L-threonate," PubMed Central, 2020. ↩