Peptide 185, also referred to as KLAKLAKKLAKLAK (abbreviated as KLA), is identified as a proapoptotic peptide. This peptide has drawn interest in scientific research, particularly in the context of its ability to induce apoptosis, which is a programmed cell death mechanism¹.

The peptide has been analyzed for its potential impact on α-synuclein oligomers (αSOs) which are linked to several cellular dysfunctions, including the permeabilization of cellular membranes and cytotoxicity. Peptide 185 is derived from penetratin, a cell-penetrating peptide, but it holds distinctive proapoptotic properties².

Given its apoptotic action, peptide 185 may be explored for targeted therapy in cancer treatment as well as in other conditions where inducing apoptotic pathways can be beneficial. However, more research is needed to fully elucidate its mechanisms and potential therapeutic applications².

Footnotes

1. Mitra Pirhaghi, "A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers," PubMed Central, 2022. ↩

2. Mitra Pirhaghi, "A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers," PubMed Central, 2022. ↩ ↩²

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