When it comes to the prevention and support of skin cancer, certain supplements have shown promise based on scientific research. Here are some notable supplements and their roles:

1. Nicotinamide (Vitamin B3):

   • Nicotinamide, a form of Vitamin B3, has been shown to reduce the rate of new squamous-cell and basal-cell skin cancers by 23% in individuals at high risk¹. It's important to note that continuous treatment is advised, and nicotinamide is preferred over other forms like niacin.

2. Antioxidants:

   • Antioxidants play a vital role in reducing oxidative stress caused by UV radiation, which is a major environmental factor in skin cancer development. Increased levels of antioxidant defense can help scavenge reactive oxygen species (ROS)². These include vitamins like Vitamin C, Vitamin E, and certain polyphenolic compounds.

3. Retinoids (Vitamin A):

   • Retinoids, which include Vitamin A and its derivatives, have been studied for their potential in skin cancer prevention. High doses of isotretinoin, a retinoid, have shown effectiveness in preventing new skin cancers in individuals with certain genetic conditions³.

4. Vitamin D:

   • The relationship between Vitamin D and skin cancer is complex and somewhat controversial. While some evidence suggests that adequate levels of Vitamin D might help in preventing certain types of skin cancer, other studies indicate potential associated risks with high levels⁴. It's generally recommended to obtain Vitamin D preferably through diet rather than UV exposure due to the risk of skin damage.

5. Selenium:

   • Selenium has been studied for its chemopreventive properties in skin cancer. However, its effectiveness remains inconclusive, necessitating further research³.

It is crucial to understand that while these supplements may aid in skin cancer prevention and management, they should complement primary preventive measures such as avoiding excessive sun exposure, using sunscreen, and regular dermatological check-ups.

Footnotes

1. Phoebe Starr, "Oral Nicotinamide Prevents Common Skin Cancers in High-Risk Patients, Reduces Costs," PMC, 2024. ↩

2. Aleksandar Godic, "The Role of Antioxidants in Skin Cancer Prevention and Treatment," PMC, 2014. ↩

3. PDQ Screening and Prevention Editorial Board, "Skin Cancer Prevention (PDQ®) - NCBI Bookshelf," NCBI, 2024. ↩ ↩²

4. Alejandro Martin-Gorgojo, "Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review," PMC, 2021. ↩