Immune Responses Induced by Lion’s Mane and Turkey Tail Mushrooms: Th1 vs. Th2
This session discusses the immune responses induced by Lion's Mane and Turkey Tail mushrooms. It highlights their role in promoting a Th1 response, which aids in fighting intracellular pathogens and tumors, and enhances cellular immunity against cancer and viral infections.
Lion's mane induces Th1 response or Th2 response?
Lion's mane (Hericium erinaceus) primarily induces a Th1 immune response. This response is characterized by the stimulation of cytokines like IFN-γ, IL-2, and IL-1212. Th1 responses are generally involved in promoting cellular immune responses, which are particularly beneficial for fighting intracellular pathogens and tumors.
Footnotes
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Geir Hetland, "Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies," PubMed Central, 2020. ↩
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Alena G. Guggenheim, "Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology," PubMed Central, 2015. ↩
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Turkey tail fruit body extract induces Th1 response or Th2 response?
Turkey tail mushroom (Trametes versicolor), particularly its polysaccharopeptide (PSP) and polysaccharide-K (PSK) extracts, primarily induces a Th1 immune response. This response is characterized by the stimulation of cytokines such as IFN-γ, IL-12, and TNF-α, enhancing cellular immunity which is beneficial for combatting cancer and viral infections1.
Footnotes
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Alena G. Guggenheim, "Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology," PubMed Central, 2015. ↩
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