Several supplements may help manage Mast Cell Activation Syndrome (MCAS) by stabilizing mast cells and reducing inflammation:

1. Vitamin D:

   • Vitamin D is important for the maintenance of mast cell stability. Studies have shown that vitamin D deficiency can lead to mast cell activation¹².

2. Quercetin:

   • Quercetin is a flavonoid known for its anti-inflammatory properties. It is more effective than cromolyn in blocking human mast cell cytokine release and has been shown to reduce the symptoms of contact dermatitis and photosensitivity³⁴.

3. NAD+ Precursors (Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR)):

   • NAD+ boosting molecules help suppress mast cell degranulation and anaphylactic responses by repressing intracellular signaling pathways⁵⁶.

4. Resveratrol:

   • Resveratrol is a natural polyphenol found in red grapes that inhibits mast cell activation and reduces the release of cytokines and chemokines. It has anti-inflammatory effects and could be considered as a nutraceutical for mast cell-associated diseases⁷⁸.

5. Vitamin C:

   • Vitamin C has general anti-inflammatory properties and can help reduce histamine levels in the body, thereby stabilizing mast cells⁹.

These supplements can help mitigate symptoms by stabilizing mast cells and reducing the release of inflammatory mediators. However, it is important to consult with a healthcare provider before starting any new supplement regimen for MCAS.

Footnotes

1. Z-Q Liu, "Vitamin D contributes to mast cell stabilization - PubMed," PubMed, 2017. ↩

2. Giuseppe Murdaca, "Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases," NCBI, 2022. ↩

3. Zuyi Weng, "Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans," NCBI, 2012. ↩

4. Sina Kaag, "Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?" NCBI, 2023. ↩

5. Hyun-Woo Kim, "NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice," NCBI, 2022. ↩

6. Mark F McCarty, "Nutraceutical Aid for Allergies – Strategies for Down-Regulating Mast Cell Degranulation," NCBI, 2021. ↩

7. Sabrina Bilotta, "Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3," NCBI, 2021. ↩

8. Rachel da Silveira Gorman, "Connecting the Dots in Emerging Mast Cell Research," NCBI, 2022. ↩

9. Leonard B. Weinstock, "Neuropsychiatric Manifestations of Mast Cell Activation Syndrome and Response to Mast-Cell-Directed Treatment: A Case Series," NCBI, 2023. ↩