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Exploring the Benefits of Probiotics for Prader-Willi Syndrome

This session discusses potential benefits of probiotics for individuals with Prader-Willi Syndrome, including gastrointestinal health, gut microbiota modulation, and improvements in metabolic and mental health. Research highlights specific probiotic strains shown to alleviate symptoms associated with PWS.

  • can probiotics help with prader-willsi syndrome

  • Probiotics may offer benefits for individuals with Prader-Willi Syndrome (PWS), particularly in addressing gastrointestinal issues and influencing overall health and well-being.

    1. Gastrointestinal Health: PWS patients often experience constipation. Probiotics like Bifidobacterium animalis ssp. lactis B94 have shown improvements in stool frequency, stool form, and gastrointestinal symptoms in adults with PWS12.

    2. Gut Microbiota Modulation: Studies have documented changes in gut and salivary microbiota profiles with probiotic supplementation. These changes are often associated with improvements in clinical symptoms such as obesity and insulin tolerance345.

    3. Metabolic and Mental Health: Probiotic strains like Limosilactobacillus reuteri LR-99 and Bifidobacterium animalis subsp. lactis BPL1™ have demonstrated benefits in reducing BMI, improving social communication, fine motor skills, and attenuating age- and stress-related behaviors67.

    4. Constipation and Laxation: Clinical trials have focused on probiotics to improve laxation in adults with PWS. For example, Bifidobacterium animalis ssp. lactis B94 has been shown to improve stool frequency and gastrointestinal symptoms in randomized controlled trials15.

    While these findings are promising, further research is needed to solidify the therapeutic potential of probiotics in PWS patients. It's advisable to consult with healthcare professionals before starting any new supplement regimen.

    Footnotes

    1. Zainab Alyousif, "The effects of Bifidobacterium animalis ssp. lactis B94 on gastrointestinal wellness in adults with Prader–Willi syndrome," PubMed Central, 2018. ↩ ↩2

    2. Marta Ramon-Krauel, "Targeting the Gut Microbiome in Prader-Willi Syndrome," PubMed Central, 2021. ↩

    3. Kevin Liu, "Altered Salivary Microbiota Following Bifidobacterium animalis Subsp. Lactis BL-11 Supplementation," PubMed Central, 2022. ↩

    4. Ye Peng, "The Gut Microbiota Profile in Children with Prader–Willi Syndrome," PubMed Central, 2020. ↩

    5. Zainab Alyousif, "Microbiota profile and efficacy of probiotic supplementation on laxation in adults affected by Prader-Willi Syndrome," PubMed Central, 2025. ↩ ↩2

    6. Xue-Jun Kong, "The Effects of Limosilactobacillus reuteri LR-99 Supplementation," PubMed Central, 2021. ↩

    7. Ferran Balaguer, "Bifidobacterium animalis subsp. lactis BPL1™ and Its Lipoteichoic Acid Modulate Longevity," PubMed Central, 2023. ↩

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