Premature ejaculation (PE) is a common issue and various supplements and treatments have been researched for its management. Here are some key supplements that have shown potential benefits based on the research:

1. Vitamin B12: A study has demonstrated that lower vitamin B12 levels are associated with the presence of PE. PE patients reported significantly lower vitamin B12 levels compared with controls¹.

2. Folic Acid: Supplementation with folic acid has been investigated as an adjunctive treatment for PE. Some studies suggest that it can be beneficial in managing PE².

3. Vitamin D: There is a correlation between lower serum vitamin D levels and an increased likelihood of acquired PE. Supplementation of vitamin D might help improve sexual health in men with acquired PE³.

4. Rhodiola Rosea, Zinc, Biotin, Folic Acid Combination (EndEP®): This specific combination has shown to significantly improve ejaculatory control and the quality of sexual life in patients affected by lifelong PE⁴.

5. 5-Hydroxytryptamine (5-HT or Serotonin): Increasing serotonin levels with the help of Selective Serotonin Reuptake Inhibitors (SSRIs) has been effective in delaying ejaculation in humans and is often used 'off-label' for treating PE⁵.

If you are interested in specific product recommendations containing any of these supplements, please let me know!

Footnotes

1. Relation between blood vitamin B12 levels with premature ejaculation: case-control study ↩

2. Folic acid supplementation as adjunctive treatment premature ejaculation ↩

3. Low serum vitamin D is associated with an increased likelihood of acquired premature ejaculation ↩

4. Rhodiola rosea, folic acid, zinc, and biotin (EndEP®) in patients with lifelong PE ↩

5. 5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention ↩

If you are considering using only one supplement or pill for managing premature ejaculation (PE), it is essential to choose one that has shown significant effectiveness and has supporting scientific evidence. Based on the available research, Dapoxetine stands out as a potent and specifically developed medication for the treatment of PE. Here are some details about Dapoxetine:

1. Dapoxetine:
   • Mechanism of Action: It is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the synaptic cleft by inhibiting its uptake. This action helps delay ejaculation¹.
   • Usage: Dapoxetine is used as an "on-demand" medication, taken 1-3 hours before sexual activity. The initial recommended dose is 30 mg, which can be increased to 60 mg if lower doses are insufficient².
   • Effectiveness: Clinical studies have shown that Dapoxetine can significantly increase the intravaginal ejaculatory latency time (IELT). For example, at a dose of 30 mg, it can increase IELT to 2.8-3.9 minutes, and at 60 mg, to 3.3-4.2 minutes compared to the placebo².
   • Safety and Side Effects: Dapoxetine is generally considered safe. Common side effects may include nausea, headache, diarrhea, dizziness, and insomnia. It does not typically cause erectile dysfunction².

Dapoxetine's specific design for the treatment of PE, combined with its effective and quick action, makes it a strong candidate if you are considering a single supplement or pill.

If you want to look for products containing Dapoxetine or any other PE supplement, I can help you find some options. Let me know if you would like to proceed with a product search!

Footnotes

1. Premature ejaculation - current concepts in the management: A narrative review ↩

2. [Premature ejaculation - current concepts in the management: A narrative review](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC785148 ↩ ↩² ↩³

No, Dapoxetine and Tongkat Ali are not the same. They differ significantly in their composition, mechanism of action, and usage:

1. Dapoxetine:

   • Classification: It is a pharmaceutical drug, specifically a Selective Serotonin Reuptake Inhibitor (SSRI).
   • Mechanism of Action: Dapoxetine increases serotonin levels in the synaptic cleft by inhibiting its reuptake. This increase in serotonin helps delay ejaculation, making it effective for treating premature ejaculation (PE)¹.
   • Usage: It is generally taken as an "on-demand" medication, about 1-3 hours before sexual activity.
   • Effectiveness: Proven to increase intravaginal ejaculatory latency time (IELT) significantly in clinical trials².

2. Tongkat Ali (Eurycoma longifolia):

   • Classification: It is a herbal supplement, commonly used as an aphrodisiac and for enhancing testosterone levels.
   • Mechanism of Action: Tongkat Ali is believed to work by enhancing the body's natural production of testosterone, thereby improving libido, sexual performance, and overall energy levels³.
   • Usage: Typically taken regularly over a period of time as a supplement.
   • Effectiveness: While Tongkat Ali is noted for its general benefits on male sexual health, including increasing sexual motivation and performance, its specific effectiveness in treating PE is less studied compared to Dapoxetine⁴.

If you are specifically looking for a treatment for premature ejaculation, Dapoxetine has more direct clinical evidence supporting its use for this condition. Tongkat Ali may offer broader benefits for sexual health and libido but is not specifically targeted for PE.

Footnotes

1. Premature ejaculation - current concepts in the management: A narrative review ↩

2. Premature ejaculation - current concepts in the management: A narrative review ↩

3. Asian herbals and aphrodisiacs used for managing ED ↩

4. Asian herbals and aphrodisiacs used for managing ED ↩