PT-141, also known as Bremelanotide, is a synthetic peptide developed as a melanocortin agonist primarily targeting the melanocortin receptors MC3R and MC4R in the central nervous system¹. It has been shown to facilitate penile erections in animal studies and to activate neurons in the hypothalamus¹. Clinical trials have demonstrated that PT-141 can be effective in increasing erectile activity in men, including those with erectile dysfunction¹.

Moreover, PT-141 has been studied for its effects on sexual dysfunction in both men and women. In women, PT-141 has shown potential as a treatment for hypoactive sexual desire disorder (HSDD), improving symptoms in several clinical trials².

Sources

Comparison of Trimix and PT-141 for Erectile Dysfunction

Trimix and PT-141 are both used to treat erectile dysfunction (ED), but they have different mechanisms of action, administration methods, and efficacy profiles.

Trimix

Trimix is a combination therapy consisting of alprostadil, papaverine, and phentolamine:

• Alprostadil: Prostaglandin E1, which causes vasodilation and increased blood flow.
• Papaverine: Phosphodiesterase inhibitor that helps relax the smooth muscles of blood vessels.
• Phentolamine: Non-selective alpha-adrenergic antagonist that promotes arterial dilation.

Administration: Intracavernosal (direct injection into the penis).

Efficacy:

• Highly effective in producing erections sufficient for sexual intercourse.
• Commonly used in patients who do not respond to oral PDE5 inhibitors like sildenafil.

Side Effects:

• Pain at the injection site.
• Priapism (prolonged erections).
• Penile fibrosis (scar tissue formation).

Advantages:

• Immediate action.
• High success rate in non-responders of oral medications.

PT-141 (Bremelanotide)

PT-141 is a synthetic peptide and melanocortin receptor agonist that primarily targets MC3R and MC4R in the central nervous system:

• Facilitates penile erections and enhances sexual arousal by upregulating dopamine pathways.

Administration: Intranasal spray or subcutaneous injection.

Efficacy:

• Intranasal: Quick onset of action with effects starting within minutes.
• Effective in both males and females, particularly in psychogenic and organic ED.
• Shown to improve erectile function in those non-responsive to PDE5 inhibitors.

Side Effects:

• Nausea and vomiting.
• Flushing and headaches.
• Increased blood pressure concerns in some clinical trials.

Advantages:

• Can induce erections without the need for visual or tactile sexual stimulation.
• Offers an alternative for patients unable or unwilling to use injection therapies.

Clinical Findings

1. Trimix:

   • Direct intracavernosal injection leads to predictably strong and immediate erections¹.
   • Useful for men with severe ED where other treatments have failed.

2. PT-141:

   • Acts centrally on the brain rather than directly on penile blood vessels².
   • Effective in various ED contexts, including psychogenic ED where central stimulation is crucial³.

Conclusion

Trimix is generally recognized for its immediate and potent effects due to direct penile injection, making it a robust choice for severe cases. On the other hand, PT-141 offers a less invasive option that can initiate an erection without physical stimuli, with broader applications in both male and female sexual dysfunction. However, PT-141 may come with central nervous system side effects, which need to be carefully managed.

References

I can't provide specific vendor recommendations or check for suppliers, but you can look for PT-141 from trustworthy, regulated sources to ensure safety and authenticity. Purchasing from highly reputable online pharmacies or local suppliers in Australia that comply with TGA (Therapeutic Goods Administration) regulations is generally advisable.

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