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A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial.

  • 2020-05
  • Digestive and Liver Disease 52(5)
    • S. Sadrin
    • S. Sennoune
    • B. Gout
    • S. Marque
    • J. Moreau
    • Karim Zinoune
    • J. Grillasca
    • O. Pons
    • J. Maixent

Abstract

Background: In the absence of a well-established therapeutic approach, patients with irritable bowel syndrome seek alternative strategies such as probiotics.

Aims: The current trial named LAPIBSS aimed to demonstrate the efficacy of a 2-strain mixture of Lactobacillus acidophilus to improve irritable bowel syndrome symptoms.

Methods: Eighty patients diagnosed for irritable bowel syndrome were recruited to a multicentre, double-blinded, in parallel groups, placebo-controlled, randomized clinical trial. Patients were provided with a daily dose of two capsules containing either probiotics (5 × 109 cfu/capsule) or placebo for 8 weeks. The primary outcome was abdominal pain score assessed with a 100-mm visual analogue scale. Secondary outcomes included scores of bloating, flatus and rumbling assessed with a 100-mm visual analogue scale, a composite score and bowel habits.

Results: Abdominal pain score was significantly improved in both groups at weeks 4 and 8 (P < 0.0001), but no significant differences were found between groups at week 8 (19.0 ± 2.5 vs 25.1 ± 2.6, respectively; LS Means differences = 6.0 ± 3.2; P = 0.06). Significant differences between groups were observed for flatus score at week 4 (P = 0.04) and week 8 (P = 0.03) and composite score (P = 0.04) at week 8.

Conclusions: The consumption of the 2-strain mixture of L. acidophilus over 8 weeks is safe and decreases significantly flatus and composite scores.

Trial registration number: EudraCT No 2008 A00844-51.

Keywords: Functional gastrointestinal disorders; Lactic acid bacteria; Microbiota; Probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusImproved IBS Composite Symptom ScoreBeneficial
Moderate
Lactobacillus acidophilusReduced Abdominal PainNeutral
Small
Lactobacillus acidophilusReduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus HA-122Improved Composite Score of Irritable Bowel Syndrome SymptomsBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus L-92Reduced Abdominal PainNeutral
Small
Lactobacillus acidophilus L-92Reduced Composite ScoreBeneficial
Moderate
Lactobacillus acidophilus L-92Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Abdominal PainNeutral
Small
Lactobacillus acidophilus LA-02Improved FlatusBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Gastrointestinal Symptom ScoreBeneficial
Moderate
Lactobacillus acidophilus LA1Decreased Composite ScoresBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Abdominal Pain SeverityNeutral
Moderate
Lactobacillus acidophilus LA1Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Improved Gastrointestinal SymptomsBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Abdominal PainNeutral
Small
Lactobacillus acidophilus NCIMB 30333Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced Composite Symptom ScoreBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus SD-5212Improved Composite Symptom ScoreBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Abdominal PainNeutral
Small
Lactobacillus acidophilus SD-5212Reduced FlatulenceBeneficial
Moderate
Lactobacillus acidophilus UALa01Improved Gastrointestinal ScoreBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Abdominal PainNeutral
Small
Lactobacillus acidophilus UALa01Reduced FlatulenceBeneficial
Moderate
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