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A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

  • 2020
  • Bioscience of Microbiota, Food and Health 39(1)
    • Y. Gotoh
    • Fumio Nanba
    • Nobuhiko Shioya
    • Haruhi Sugimura
    • Toshio Suzuki


A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 107 cfu; dose level 2, 2 × 107 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 107 cfu L. cremoris FC improves defecation.

Keywords: Lactococcus lactis; defecation; dose-escalation study; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus cremorisImproved Bowel Movement FrequencyBeneficial
Lactococcus cremorisIncreased Stool VolumeBeneficial
Lactococcus cremoris VPro 41Increased Bowel Movement FrequencyBeneficial
Lactococcus cremoris VPro 41Increased Stool VolumeBeneficial

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