A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

2020-09-28
Bioscience of Microbiota, Food and Health 39(1)
- Y. Gotoh
- Fumio Nanba
- Nobuhiko Shioya
- Haruhi Sugimura
- Toshio Suzuki

PubMed: 32010540
DOI: 10.12938/bmfh.19-009

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 27
Population: Healthy adults
Methods: Dose-escalation study

Abstract

A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 107 cfu; dose level 2, 2 × 107 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 107 cfu L. cremoris FC improves defecation.

Keywords: Lactococcus lactis; defecation; dose-escalation study; probiotics.

Research Insights

Lactococcus cremoris VPro 41→Increased Bowel Movement Frequency
Frequency of defecation (times/week) was significantly increased by dose level 2.
Effect
Beneficial
Effect size
Large
Lactococcus cremoris VPro 41→Increased Stool Volume
Stool volume (units/week) was significantly increased by dose level 1.
Effect
Beneficial
Effect size
Moderate