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A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

  • 2020
  • Bioscience of Microbiota, Food and Health 39(1)
    • Y. Gotoh
    • Fumio Nanba
    • Nobuhiko Shioya
    • Haruhi Sugimura
    • Toshio Suzuki

Abstract

A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 107 cfu; dose level 2, 2 × 107 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 107 cfu L. cremoris FC improves defecation.

Keywords: Lactococcus lactis; defecation; dose-escalation study; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus cremorisImproved Bowel Movement FrequencyBeneficial
Moderate
Lactococcus cremorisIncreased Stool VolumeBeneficial
Moderate
Lactococcus cremoris VPro 41Increased Bowel Movement FrequencyBeneficial
Large
Lactococcus cremoris VPro 41Increased Stool VolumeBeneficial
Moderate

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