A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
- 2020
- Bioscience of Microbiota, Food and Health 39(1)
- Y. Gotoh
- Fumio Nanba
- Nobuhiko Shioya
- Haruhi Sugimura
- Toshio Suzuki
- PubMed: 32010540
- DOI: 10.12938/bmfh.19-009
Abstract
A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 107 cfu; dose level 2, 2 × 107 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 107 cfu L. cremoris FC improves defecation.
Keywords: Lactococcus lactis; defecation; dose-escalation study; probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactococcus cremoris | Improved Bowel Movement Frequency | Beneficial | Moderate |
| Lactococcus cremoris | Increased Stool Volume | Beneficial | Moderate |
| Lactococcus cremoris VPro 41 | Increased Bowel Movement Frequency | Beneficial | Large |
| Lactococcus cremoris VPro 41 | Increased Stool Volume | Beneficial | Moderate |