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A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with Lactococcus lactis 11/19-B1 and Bifidobacterium lactis on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-γ Releasing Ability

  • 2018-11-16
  • Nutrients 10(11)
    • K. Nishiyama
    • Takahiro Kobayashi
    • Yuko Sato
    • Yoshihisa Watanabe
    • Riki Kikuchi
    • Ryoko Kanno
    • T. Koshizuka
    • Nozomu Miyazaki
    • Ken Ishioka
    • T. Suzutani

Abstract

In order to clarify the effects of the Lactococcus lactis (L. lactis) 11/19-B1 strain, a double-blind controlled study of yogurt fermented with the strain was carried out. For the study, two kinds of yogurt, the control and test yogurt, were prepared; the control yogurt was fermented with Streptococcus thermophiles, Lactobacillus delbrueckii subspecies bulgaricus, and Lactobacillus acidophilus, and the test yogurt was enriched with L. lactis 11/19-B1 and Bifidobacterium lactis (B. lactis) BB-12 strains. Seventy-six volunteers who had not received treatment with pharmaceuticals were randomly divided into two groups with each group ingesting 80 g of either the test or control yogurt every day for 8 weeks. Before and after yogurt intake, fasting blood was taken and blood sugar, blood lipids, and anti-cytomegalovirus cellular immunity were estimated. In the test yogurt group, low-density lipoprotein (LDL) was significantly decreased (159.1 ± 25.7 to 149.3 ± 24.4; p = 0.02), but this effect was not observed in the control yogurt group. When the test yogurt group was divided into two groups based on LDL levels of over or under 120 mg/dL, this effect was only observed in the high LDL group. No LDL-lowering effect of B. lactis BB-12 strain was previously reported; therefore, the hypocholesterolemic effects observed in this study are thought to be caused by the L. lactis 11/19-B1 strain alone or its combination with the B. lactis BB-12 strain.

Keywords: Lactococcus lactis; double-blind controlled study; low-density lipoprotein; yogurt.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus lactisReduced LDL Cholesterol LevelsBeneficial
Moderate
Lactococcus lactis L1A-23Reduced LDL CholesterolBeneficial
Moderate
Lactococcus lactis LL-23Reduced LDL CholesterolBeneficial
Moderate
Lactococcus lactis MJC18Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactococcus lactis SD-5584Reduced LDL LevelsBeneficial
Moderate
Lactococcus lactis SD-5584Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactococcus lactis UALl-08Reduced LDL Cholesterol LevelsBeneficial
Moderate
Lactococcus lactis UALl-08Reduced LDL LevelsBeneficial
Moderate
Lactococcus lactis VPro 34Reduced LDL Cholesterol LevelsBeneficial
Moderate
Lactococcus lactis VPro 42Reduced LDL CholesterolBeneficial
Moderate
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