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A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis.

  • 2012-04
  • The British journal of oral & maxillofacial surgery 50(3)
    • Joy Bardy
    • Alex Molassiotis
    • W David Ryder
    • Kathleen Mais
    • Andrew Sykes
    • Beng Yap
    • Lip Lee
    • Ed Kaczmarski
    • Nicholas Slevin

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 131
Population
131 patients diagnosed with head and neck cancer who were having radiotherapy to the oral cavity or oropharyngeal area
Methods
randomly allocated to take either manuka honey or placebo (golden syrup) 20 ml 4 times daily for 6 weeks
Blinding
Double-blind
Duration
6 weeks
  • Large Human Trial
Our aim was to investigate the effect of active manuka honey on radiation-induced mucositis. A total of 131 patients diagnosed with head and neck cancer who were having radiotherapy to the oral cavity or oropharyngeal area were recruited into the study, and were randomly allocated to take either manuka honey or placebo (golden syrup) 20 ml 4 times daily for 6 weeks. Mucositis was assessed according to the Radiation Therapy Oncology Group (RTOG) scale at baseline, weekly during radiotherapy, and twice weekly thereafter until the mucositis resolved. The patient's weight was recorded at the same time as the mucositis was assessed. Throat swabs to identify bacterial or fungal infections were taken at baseline, and during and after radiotherapy. There was no significant difference between honey and golden syrup in their effects on mucositis. Active manuka honey did not improve mucositis, but both the honey and the syrup seemed to be associated with a reduction in bacterial infections. Compliance was a problem after the onset of mucositis, which may have affected the findings.

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