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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis.

  • 2015-11-28
  • Journal of Microbiology and Biotechnology 25(11)
    • Hye-iin Kim
    • I. Rather
    • Hyunwook Kim
    • Sungsoo Kim
    • Taeeun Kim
    • Jaeyoung Jang
    • Jimin Seo
    • Jeongheui Lim
    • Yong-Ha Park

Abstract

Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).

Keywords: Canine atopic dermatitis; Lactobacillus sakei; probiotics; skin disorder.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus sakei proBio65Reduced CASESI Score in Canine Atopic DermatitisBeneficial
Moderate
Lactobacillus sakei proBio65Reduced Disease Severity in Canine Atopic DermatitisBeneficial
Moderate
Lactobacillus sakei proBio65Reduced PVAS Score in Canine Atopic DermatitisBeneficial
Moderate
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