A Review of the Effects of Collagen Treatment in Clinical Studies.

2021-11-09
Polymers 13(22)
- Hsiuying Wang

PubMed: 34833168
DOI: 10.3390/polym13223868

Study Design

Type: Review

Highly Cited

Collagen, an abundant extracellular matrix protein, has been found to have a lot of pharmaceuticals, medicine, food, and cosmetics applications. Increased knowledge of collagen sources, extraction techniques, structure, and properties in the last decades has helped develop more collagen-based products and tissue engineering biomaterials. Collagen products have been playing an important role in benefiting the health of the human body, especially for aging people. In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies. In addition, the associations between these diseases were discussed. The comorbidity of these diseases might be closely related to collagen deficiency, and collagen treatment might be a good choice when a patient has more than one of these diseases, including the coronavirus disease 2019 (COVID-19). It concludes that collagen-based medication is useful in treating comorbid diseases and preventing complications.

Research Insights

Collagen→Improved Bone Defect Healing
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Bone Defect Repair
The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Dental Therapy Outcome
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Gastroesophageal Reflux
The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Gastroesophageal Reflux Symptoms
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Osteoarthritis
The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Osteoarthritis Symptoms
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Rheumatoid Arthritis
The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Rheumatoid Arthritis Symptom
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Sarcopenia
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Skin Regeneration
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate
Collagen→Improved Wound Healing
In this paper, the effects of collagen treatment in different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis have been reviewed. The collagen treatments were significant in these clinical studies.
Effect
Beneficial
Effect size
Moderate