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A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota.

  • 2017-06-08
  • Molecular Nutrition & Food Research 61(8)
    • Belén Rivero-Gutiérrez
    • Reyes Gámez-Belmonte
    • M. D. Suárez
    • J. Lavín
    • A. Aransay
    • M. Olivares
    • O. Martínez-Augustin
    • F. Sánchez de Medina
    • A. Zarzuelo


We investigated the effect of a high fructose diet (HFD) on Sprague Dawley rats and the impact of a synbiotic composed of Lactobacillus fermentum CECT5716 and fructooligosaccharides. Feeding the HFD for 5 weeks resulted in liver steatosis and insulin resistance but not obesity. These changes were associated with increased production of short-chain fatty acids and increased Bacteroidetes in feces, with an augmented Bacteroidetes/Firmicutes ratio, among other changes in the microbiota. In addition, barrier function was weakened, with increased LPS plasma levels. These data are consistent with increased fructose availability in the distal gut due to saturation of absorptive mechanisms, leading to dysbiosis, endotoxemia, hepatic steatosis, and insulin resistance. Treatment with the synbiotic prevented some of the pathological effects, so that treated rats did not develop steatosis or systemic inflammation, while dysbiosis and barrier function were greatly ameliorated. In addition, the synbiotic had hypolipidemic effects. The synbiotic composed by L. fermentum CECT5716 and fructooligosaccharides has beneficial effects in a model of metabolic syndrome induced by a HFD, suggesting it might be clinically useful in this type of condition, particularly considering that high fructose intake has been related to metabolic syndrome in humans.

Keywords: Barrier function; Fructose; Leptin; Metabolic syndrome; Microbiota.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentum CECT5716Improved Intestinal Barrier FunctionBeneficial
Lactobacillus fermentum CECT5716Prevention of Liver SteatosisBeneficial
Lactobacillus fermentum CECT5716Reduced InflammationBeneficial

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