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A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

  • 2022-02-06
  • Nutrients 14(3)
    • Haixin Cheng
    • Yi Ma
    • Xiaohui Liu
    • Chao Tian
    • Xuli Zhong
    • Libo Zhao

Abstract

The efficacy of probiotic strains of Lactobacillus acidophilus to manage acute gastroenteritis in children is still not established. We searched the Cochrane Library, PubMed, EMBASE, and three Chinese literature databases (CNKI, WanFang, and CBM) from their inception to February 2021 for RCTs that compared the use of Lactobacillus acidophilus with no Lactobacillus acidophilus. The grey literature was searched through Google Scholar. Authors of the original papers were contacted for additional data. The study included a total of 15 RCTs involving 1765 patients. Compared with placebo or no treatment, Lactobacillus acidophilus was associated with a reduced duration of diarrhea (moderate quality of evidence), but the effect was not statistically significant when only the individual probiotic strain was provided. Lactobacillus acidophilus was effective when used at a daily dose ≥ 109 CFU. There was no difference in the effect of Lactobacillus acidophilus on diarrhea duration among Asian, European, or American countries. Lactobacillus acidophilus reduced the frequency of diarrhea on day 2 to day 5. However, it was statistically significant on day 3. When administered at a dosage of more than 109 CFU to children with acute gastroenteritis, moderate- to low-quality data showed that Lactobacillus acidophilus reduced the duration of diarrhea and conferred a benefit for frequency of diarrhea.

Keywords: Lactobacillus acidophilus; acute gastroenteritis; children; meta-analysis; systematic review.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusReduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilusReduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus HA-122No Change in Diarrhea DurationNeutral
Small
Lactobacillus acidophilus HA-122Reduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus LA-02Reduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilus LA-02Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Diarrhea FrequencyBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Duration of DiarrheaBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Frequency of DiarrheaBeneficial
Small

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