A tale of caution: prolonged Bacillus clausii bacteraemia after probiotic use in an immunocompetent child
- 2021-03-01
- Access Microbiology 3(3)
- A. Khatri
- S. Rai
- C. Shank
- A. McInerney
- B. Kaplan
- Stefan H F Hagmann
- Mundeep K Kainth
- PubMed: 34151160
- DOI: 10.1099/acmi.0.000205
Abstract
Introduction: Bacillus clausii as a probiotic supplement is increasingly used in both adult and paediatric patient populations. There is limited awareness about potential adverse effects.
Case presentation: We report a case of prolonged (111 days) B. clausii bacteraemia after brief probiotic use in a 17-month-old immunocompetent child, without a definite focus of infection and in the absence of predisposing risk factors or underlying co-morbidities. We identified seven probiotic use-associated cases of prolonged B. clausii bacteraemia (mean duration [range] 64 days [14-93 days] where data were available) in the literature, all with underlying co-morbidities.
Conclusion: B. clausii probiotic preparations may cause prolonged bacteraemia, rendering patients with underlying co-morbidities as well as those with unrecognized risk factors vulnerable for significant infectious complications.
Keywords: Bacillus clausii; bacteraemia; probiotic.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Bacillus clausii | Prolonged Bacteraemia | Harmful | Large |
Bacillus clausii SNZ-1971 | Prolonged Bacteraemia | Harmful | Large |