Acute postprandial effect of yacon syrup ingestion on appetite: A double blind randomized crossover clinical trial.

2020-09-03
Food research international (Ottawa, Ont.) 137
- Lia Silveira Adriano
- Ana Paula Dionísio
- Fernando Antônio Pinto de Abreu
- Nedio Jair Wurlitzer
- Bárbara Rebeca Cordeiro de Melo
- Antônio Augusto Ferreira Carioca
- Helena Alves de Carvalho Sampaio

PubMed: 33233227
DOI: 10.1016/j.foodres.2020.109648

Study Design

Type: Randomized Controlled Trial (RCT)
Population: 40 adult women: 20 eutrophic and 20 obese grade I
Methods: Double-blind crossover clinical trial, acute postprandial effect, ingestion of breakfast with 40g of placebo or yacon syrup (14g FOS), blood collection at 0, 45, 60, 90, 120, and 180 min
Blinding: Double-blind
Duration: 180 minutes
Funding: Unclear

Yacon syrup is a rich source of fructooligosaccharides (FOS); however, its diet supplementation effect on subjective sensation and appetite biomarkers in human is still unknown. This study aimed to evaluate the acute postprandial effect of yacon syrup ingestion on appetite. The double-blind crossover clinical trial was carried out with 40 adult women: 20 eutrophic and 20 obese grade I. On each day, the first blood collection was performed after a 12-h fast. Then, the volunteers ingested either intervention A (breakfast + 40 g of placebo) or intervention B (breakfast + 40 g of yacon syrup, containing 14 g of FOS). New aliquots of blood were collected at 45, 60, 90, 120, and 180 min. Appetite was assessed by estimating ghrelin and glucagon-like peptide-1 (GLP-1) levels and by assessing subjective appetite sensation. Analysis was performed using two-way ANOVA, followed by Bonferroni's multiple comparison test. No effect of yacon syrup was observed on postprandial ghrelin and GLP-1 levels at all times evaluated. Similar observations were made after stratifying the analysis by BMI (body mass index) (eutrophic and obese). The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification. We concluded that yacon syrup had no effect on postprandial ghrelin and GLP-1 levels and on the subjective appetite sensation in young adult women.

Research Insights

Yacon→Increased Fullness Sensation
The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)
Yacon→Increased Intestinal GLP-1 Levels
No effect of yacon syrup was observed on postprandial ghrelin and GLP-1 levels at all times evaluated.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)
Yacon→Increased Satiety Sensation
The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)
Yacon→Reduced Appetite
The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)
Yacon→Reduced Ghrelin Level
No effect of yacon syrup was observed on postprandial ghrelin and GLP-1 levels at all times evaluated.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)
Yacon→Reduced Hunger Sensation
The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification.
Effect
Neutral
Effect size
Small
Dose
40 g (containing 14 g FOS)