Addition of Prebiotic Rice Bran to Ready-to-Use Therapeutic Food Modulated Changes in Body Composition Only of 6-23-Month-Old Children During Treatment for Uncomplicated Acute Malnutrition: The Solutions to Enhance Health with Alternative Treatment (SEHAT) Study.

2026-06-06
Nutrients 18(12)
- Silvia Barbazza
- Marinka van der Hoeven
- Maiza Campos Ponce
- Annika M Weber
- Moretta D Fauzi
- Damayanti D Soekarjo
- Elizabeth P Ryan
- Sonia Fortin
- Frank T Wieringa

PubMed: 42356224
DOI: 10.3390/nu18121836

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 200
Population: 200 children with different degrees of acute malnutrition
Methods: Double-blinded randomized controlled trial comparing RUTF with or without rice bran
Blinding: Double-blind
Duration: 8 weeks
Funding: Unclear

Large Human Trial
Rigorous Journal

Background: Ready-to-use therapeutic foods (RUTFs) have been developed to treat severe acute malnutrition (SAM) in children by promoting rapid weight gain, but the long-term effects have been overlooked. Incorporating prebiotic rice bran into RUTF can enhance balanced weight gain. We hypothesized that children receiving RUTF + rice bran would exhibit increased fat-free mass (FFM) and reduced body fat percentage and abdominal adiposity. Methods: A double-blinded randomized controlled trial (ClinicalTrials.gov:NCT05319717) involving 200 children with different degrees of acute malnutrition compared the effectiveness of RUTF with or without rice bran. Children received treatment for 8 weeks, with another 8 weeks of follow-up. Anthropometry, including skinfolds, was collected every 4 weeks. Results: Compliance was similar in both groups (~21%). Children aged 6 to 23 months receiving RUTF + rice bran gained more FFM than those receiving RUTF alone (p = 0.05 at week 8). Over the 8-week treatment, the fat mass index increased in children receiving RUTF (p = 0.02), but not in those receiving RUTF + rice bran (p = 0.48), although the increase in body fat percentage was similar (p = 0.23). The ratio of abdominal to peripheral skinfolds decreased in both groups during treatment but increased during follow-up, though the difference was not statistically significant. In children aged 24 to 59 months, no significant differences in body composition were observed. The fat-free mass index increased in both groups during treatment but declined afterwards, with significant changes noted in the RUTF + rice bran group. Conclusions: The addition of rice bran to RUTF affected body composition changes during treatment only in younger children, where more lean mass was gained and fat mass gain was limited. Differences in intestinal microbiome maturity might underlie this age difference.

Research Insights

rice bran→Increased Fat-Free Mass
Children aged 6 to 23 months receiving RUTF + rice bran gained more FFM than those receiving RUTF alone (p = 0.05 at week 8).
Effect
Beneficial
Effect size
Small
rice bran→Increased Fat-Free Mass Index
In children aged 24 to 59 months, no significant differences in body composition were observed. The fat-free mass index increased in both groups during treatment but declined afterwards, with significant changes noted in the RUTF + rice bran group.
Effect
Neutral
Effect size
Small
rice bran→Reduced Abdominal-to-Peripheral Skinfold Ratio
The ratio of abdominal to peripheral skinfolds decreased in both groups during treatment but increased during follow-up, though the difference was not statistically significant.
Effect
Neutral
Effect size
Small
rice bran→Reduced Body Fat Percentage
the increase in body fat percentage was similar (p = 0.23)
Effect
Neutral
Effect size
Small
rice bran→Reduced Fat Mass Index
Over the 8-week treatment, the fat mass index increased in children receiving RUTF (p = 0.02), but not in those receiving RUTF + rice bran (p = 0.48)
Effect
Neutral
Effect size
Small
rice bran→Reduced Visceral Fat
The ratio of abdominal to peripheral skinfolds decreased in both groups during treatment but increased during follow-up, though the difference was not statistically significant.
Effect
Neutral
Effect size
Small