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Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 improves acute liver injury induced by d-galactosamine in rats

  • 2014-03-18
  • Applied Microbiology and Biotechnology 98(12)
    • L. Lv
    • Xin-Jun Hu
    • Guiyun Qian
    • Hua Zhang
    • H. Lu
    • Bei-wen Zheng
    • Li Jiang
    • Lan-Juan Li

Abstract

This work investigated the effect of the intragastric administration of five lactic acid bacteria from healthy people on acute liver failure in rats. Sprague-Dawley rats were given intragastric supplements of Lactobacillus salivarius LI01, Lactobacillus salivarius LI02, Lactobacillus paracasei LI03, Lactobacillus plantarum LI04, or Pediococcus pentosaceus LI05 for 8 days. Acute liver injury was induced on the eighth day by intraperitoneal injection of 1.1 g/kg body weight D-galactosamine (D-GalN). After 24 h, samples were collected to determine the level of liver enzymes, liver function, histology of the terminal ileum and liver, serum levels of inflammatory cytokines, bacterial translocation, and composition of the gut microbiome. The results indicated that pretreatment with L. salivarius LI01 or P. pentosaceus LI05 significantly reduced elevated alanine aminotransferase and aspartate aminotransferase levels, prevented the increase in total bilirubin, reduced the histological abnormalities of both the liver and the terminal ileum, decreased bacterial translocation, increased the serum level of interleukin 10 and/or interferon-γ, and resulted in a cecal microbiome that differed from that of the liver injury control. Pretreatment with L. plantarum LI04 or L. salivarius LI02 demonstrated no significant effects during this process, and pretreatment with L. paracasei LI03 aggravated liver injury. To the best of our knowledge, the effects of the three species-L. paracasei, L. salivarius, and P. pentosaceus-on D-GalN-induced liver injury have not been previously studied. The excellent characteristics of L. salivarius LI01 and P. pentosaceus LI05 enable them to serve as potential probiotics in the prevention or treatment of acute liver failure.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusAltered Gut Microbiome CompositionNeutral
Moderate
Lactobacillus SalivariusIncreased Interleukin-10 LevelsBeneficial
Moderate
Lactobacillus SalivariusPrevented Increase in Total BilirubinBeneficial
Large
Lactobacillus SalivariusReduced Bacterial TranslocationBeneficial
Large
Lactobacillus salivarius SD-5208Altered Gut Microbiota CompositionNeutral
Small
Lactobacillus salivarius SD-5208Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced Bacterial TranslocationBeneficial
Large
Lactobacillus salivarius SD-5208Reduced Liver Enzyme LevelsBeneficial
Large
Lactobacillus salivarius SD-5208Stabilized Total Bilirubin LevelsBeneficial
Large
Lactobacillus salivarius UALs07Altered Cecal MicrobiomeBeneficial
Moderate
Lactobacillus salivarius UALs07Increased Interleukin-10 LevelsBeneficial
Moderate
Lactobacillus salivarius UALs07Prevented Increase in Total BilirubinBeneficial
Large
Lactobacillus salivarius UALs07Reduced Bacterial TranslocationBeneficial
Large
Lactobacillus salivarius UALs07Reduced Liver Enzyme LevelsBeneficial
Large
Lactobacillus salivarius VPro 15Aggravated Liver InjuryHarmful
Large
Lactobacillus salivarius VPro 15Improved Cecal Microbiome ProfileBeneficial
Moderate
Lactobacillus salivarius VPro 15Increased Interleukin-10 LevelsBeneficial
Moderate
Lactobacillus salivarius VPro 15Prevented Increase in Total BilirubinBeneficial
Large
Lactobacillus salivarius VPro 15Reduced Bacterial TranslocationBeneficial
Large
Lactobacillus salivarius VPro 15Reduced Elevated Liver EnzymesBeneficial
Large
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