Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".
- 2026-05-15
- Frontiers in pediatrics 14
- He-Xue Yuan
- Zhi-Tao Yin
- Li-Hua Wang
- Lin Ma
- Yang Liu
- Yu-Lin Ju
- Bin Yue
- PubMed: 42221001
- DOI: 10.3389/fped.2026.1789225
Study Design
- Type
- Review
Pediatric perianal abscesses represent a frequent yet underrecognized condition that poses diagnostic and therapeutic challenges due to tissue fragility and age-dependent healing dynamics. This review synthesizes current evidence on the epidemiology, pathophysiology, and management of pediatric perianal abscesses to provide a conceptual basis for clinical decision-making. Surgical interventions such as incision and drainage offer rapid symptom relief but may increase the risk of fistula formation, particularly in older children. In contrast, conservative strategies including antibiotic therapy and observation are often effective in infants and young children, reflecting their superior regenerative capacity. Age-related differences in immune response, microbiota composition, and glandular anatomy contribute to variations in disease progression and healing outcomes. By integrating data from recent studies and clinical guidelines, this review highlights the importance of individualized, age-specific management to optimize recovery, minimize recurrence, and prevent fistula development. Furthermore, it identifies gaps in current evidence and underscores the need for standardized treatment protocols and future research into predictive and microbiome-related factors influencing disease course.