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Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder

  • 2023-09-22
  • Nutrients 15(19)
    • Ruixin Kou
    • Jin Wang
    • Angyang Li
    • Yuanyifei Wang
    • Bowei Zhang
    • Jingming Liu
    • Ying Sun
    • Shuo Wang


Obesity has emerged as one of the most prevalent chronic diseases worldwide. Our study was conducted to investigate the anti-obese potential of novel probiotic Bifidobacterium longum subsp. infantis FB3-14 (FB3-14) and the underlying molecular mechanisms in high-fat diet (HFD)-fed mice. The results demonstrated that an 8-week FB3-14 intervention significantly suppressed the HFD-induced body and fat weight gain and abnormal alterations of the serum lipid parameter, restoring the levels of cholesterol (4.29 mmol/L) and low-density lipoprotein cholesterol (3.42 mmol/L). FB3-14 treatment also attenuated adipocyte expansion, hepatic injury, and low-grade systemic inflammation and restored the expressions of lipid-metabolism-related genes, including Hsl, Leptin, and Adiponectin. Furthermore, FB3-14 was observed to reduce the Firmicutes/Bacteroidetes ratio in obese mice; increase the abundance of Akkermansia muciniphila, unclassified_Muribaculaceae, Lachnospiraceae_NK4A136_group, and Bifidobacterim; and upregulate G protein-coupled receptor41 associated with higher levels of butyric acid. These results indicate the protective effectiveness of FB3-14 in HFD-driven obesity and gut microbiota disorders, highlighting the promising potential of FB3-14 as a functional nutrition supplement.

Keywords: Bifidobacterium longum subsp. infantis; gut microbiota; high-fat diet; lipid metabolism; liver function; obesity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium longum UABI-14Normalized Serum Lipid LevelsBeneficial
Bifidobacterium longum UABI-14Reduced Adipocyte SizeBeneficial
Bifidobacterium longum UABI-14Reduced Inflammation LevelsBeneficial
Bifidobacterium longum UABI-14Reduced Liver InjuryBeneficial
Bifidobacterium longum UABI-14Restored Lipid MetabolismBeneficial
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