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An Infant Milk Formula Supplemented with Heat-Treated Probiotic Bifidobacterium animalis subsp. lactis CECT 8145, Reduces Fat Deposition in C. elegans and Augments Acetate and Lactate in a Fermented Infant Slurry

  • 2020-05-19
  • Foods 9(5)
    • Ángela Silva
    • Núria González
    • A. Terren
    • Antonio G. García
    • J. Martínez-Blanch
    • Vanessa Illescas
    • Javier Morales
    • Marcos Maroto
    • S. Genovés
    • D. Ramón
    • P. Martorell
    • E. Chenoll

Abstract

Pediatric obesity has a growing health and socio-economical impact due to cardiovascular and metabolic complications in adult life. Some recent studies suggest that live or heat-treated probiotics have beneficial effects in preventing fat deposition and obesity in preclinical and clinical sets. Here, we have explored the effects of heat-treated probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (HT-BPL1), added as a supplement on an infant milk formula (HT-BPL1-IN), on Caenorhabditis elegans fat deposition and short-chain fatty acids (SCFAs) and lactate, using fermented baby fecal slurries. We have found that HT-BPL1-IN significantly reduced fat deposition in C. elegans, at the time it drastically augmented the generation of some SCFAs, particulary acetate and organic acid lactate. Data suggest that heat-treated BPL1 maintains its functional activities when added to an infant powder milk formula.

Keywords: Bifidobacterium animalis subsp. lactis; C. elegans; acetate; fat deposition; heat-treated probiotic; lactate.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalis subsp. lactis CECT 8145Enhanced SCFA ProductionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Fat AccumulationBeneficial
Large
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Elevated Lactate LevelsBeneficial
Large
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Increased Fecal Acetate LevelsBeneficial
Large
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Fat AccumulationBeneficial
Large

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