Skip to main content

Abstract

In the present study, the effect of ingested viable Lactobacillus casei Shirota strain YIT9029 on oral infection with the enteric pathogen Listeria monocytogenes in Wistar rats was investigated. Rats were orally infected with 10(9) viable L. monocytogenes. Starting 3 days before the infection, rats received a daily dosage of 10(9) viable L. casei. It was shown that supplementation of L. casei significantly reduced the numbers of L. monocytogenes in stomach, caecum, faeces, spleen and liver, 2 days after L. monocytogenes infection. The number of L. monocytogenes in the mesenteric lymph nodes was not affected by the ingestion of L. casei. In comparison with control animals, the levels of the liver-specific alanine aminotransferase were lower in L. casei-fed rats. Histological analysis of spleen and liver revealed no differences between the experimental and control animals. In a parallel study with orally L. monocytogenes infected rats, it was shown that L. casei was able to increase cellular immunity significantly as determined with the delayed-type hypersensitivity response against heat-killed L. monocytogenes. In conclusion, in the present study it was shown that orally administered L. casei is able to enhance host resistance against oral L. monocytogenes infection. In the gastrointestinal tract, as well as in the spleen and liver, L. monocytogenes numbers were reduced. Furthermore, it is concluded that the enhancement of this anti-Listeria activity might be, at least partly, due to increased cell-mediated immunity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus caseiEnhanced Natural Killer Cell Tumoricidal ActivityBeneficial
Moderate
Lacticaseibacillus caseiReduced Gastrointestinal Colonization of Listeria MonocytogenesBeneficial
Large
Lacticaseibacillus caseiReduced Serum Alanine Aminotransferase LevelsBeneficial
Moderate
Lacticaseibacillus casei R0215Enhanced Natural Killer Cell Tumoricidal ActivityBeneficial
Moderate
Lacticaseibacillus casei R0215Reduced Alanine Aminotransferase LevelsBeneficial
Moderate
Lacticaseibacillus casei R0215Reduced Gastrointestinal Colonization of Listeria MonocytogenesBeneficial
Large
Lactobacillus caseiEnhanced Natural Killer Cell Tumoricidal ActivityBeneficial
Moderate
Lactobacillus caseiReduced Aminotransferase LevelsBeneficial
Moderate
Lactobacillus caseiReduced Gastrointestinal Colonization of Listeria MonocytogenesBeneficial
Large
Lactobacillus genseniEnhanced Natural Killer Cell Tumoricidal ActivityBeneficial
Moderate
Lactobacillus genseniReduced Liver Enzyme LevelsBeneficial
Small
Lactobacillus genseniReduced Pathogen LoadBeneficial
Moderate
⬆ Back to top
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use support@pillser.com to get in touch.