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Anti-inflammatory properties of fermented soy milk with Lactococcus lactis subsp. lactis S-SU2 in murine macrophage RAW264.7 cells and DSS-induced IBD model mice.

  • 2015-06
  • International Immunopharmacology 26(2)
    • Miho Kawahara
    • Maki Nemoto
    • Toru Nakata
    • Saya Kondo
    • Hajime Takahashi
    • B. Kimura
    • T. Kuda


Six lactic acid bacteria strains (four Lactobacillus plantarum strains and one each of Lactococcus lactis subsp. lactis and Pediococcus pentosaceus) have been isolated and shown to possess anti-oxidant activity. In this study, we determined their acid, bile, salt resistance, and adhesion activity on human enterocyte-like HT-29-Luc and Caco-2 cells. An isolate Lc. lactis S-SU2 showed highest bile resistance and adhesion activity compared to type strains. S-SU2 could ferment both 10% skimmed milk and soy milk while the type strain could not ferment soy milk. Soy milk fermented with S-SU2 showed an increased nitric oxide (NO) secretion in the mouse macrophage RAW264.7 cells without bacterial lipopolysaccharide (LPS). Furthermore, the inhibitory effects of the fermented soy milk on Escherichia coli O111 LPS-induced NO secretion were higher than those of fresh soy milk. Inflammatory bowel disease (IBD) was induced in mice fed either 5% (w/v) dextran sodium sulfate (DSS) in drinking water or 50% soy milk in drinking water. Shortening of colon length, breaking of epithelial cells, lowering liver and thymus weights, and enlargement of spleen are some of the characteristics observed in the IBD, which were prevented by the use of soy milk fermented with Lc. lactis S-SU2.

Keywords: Anti-inflammation; Dextran sodium sulfate; Inflammation bowl disease; Lactococcus lactis subsp. lactis; Mice; murine macrophage RAW264.7.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus lactis subsp. lactisEnhanced Adhesion to Enterocyte-like CellsBeneficial
Lactococcus lactis subsp. lactisImproved Digestive HealthBeneficial
Lactococcus lactis subsp. lactisIncreased Bile ResistanceBeneficial
Lactococcus lactis subsp. lactisIncreased Nitric Oxide SecretionBeneficial
Lactococcus lactis subsp. lactisPrevention of Inflammatory Bowel Disease CharacteristicsBeneficial
Lactococcus lactis subsp. lactisReduced NO Secretion Induced by LPSBeneficial
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