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Anti-Inflammatory Properties of Streptococcus salivarius, a Commensal Bacterium of the Oral Cavity and Digestive Tract

  • 2014-02
  • Applied and Environmental Microbiology 80(3)
    • Ghalia Kaci
    • D. Goudercourt
    • V. Dennin
    • B. Pot
    • J. Doré
    • S. Ehrlich
    • P. Renault
    • H. Blottière
    • C. Daniel
    • C. Delorme


Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius, suggesting a protective response exclusively with metabolically active bacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus salivariusReduced Inflammation LevelsBeneficial
Streptococcus salivarius M18Reduced Inflammation LevelsBeneficial

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