Skip to main content
Supplement Research and Comparison WebsiteBest Price Guarantee
Supplement Research and Comparison Website

Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

  • 2013-01-30
  • PLoS ONE 8(1)
    • Ji-hee Kang
    • S. Yun
    • Miri Park
    • Jun-Hong Park
    • So-Young Jeong
    • Han-Oh Park

Abstract

Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley (SD) rats and reduced glucose levels in type 2 diabetes mice. In the current study, we conducted further experiments to extend these observations and elucidate the mechanism involved. C57BL/6J mice received a normal diet, high-sucrose diet or high-sucrose diet containing L. gasseri BNR17 (10(9) or 10(10) CFU) for 10 weeks. The administration of L. gasseri BNR17 significantly reduced the body weight and white adipose tissue weight regardless of the dose administered. In BNR17-fed groups, mRNA levels of fatty acid oxidation-related genes (ACO, CPT1, PPARα, PPARδ) were significantly higher and those of fatty acid synthesis-related genes (SREBP-1c, ACC) were lower compared to the high-sucrose-diet group. The expression of GLUT4, main glucose transporter-4, was elevated in BNR17-fed groups. L. gasseri BNR17 also reduced the levels of leptin and insulin in serum. These results suggest that the anti-obesity actions of L. gasseri BNR17 can be attributed to elevated expression of fatty acid oxidation-related genes and reduced levels of leptin. Additionally, data suggested the anti-diabetes activity of L. gasseri BNR17 may be to due elevated GLUT4 and reduced insulin levels.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseri BNR17Enhanced Fatty Acid Oxidation Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri BNR17Enhanced GLUT4 ExpressionBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced Body WeightBeneficial
Large
Lactobacillus gasseri BNR17Reduced Fatty Acid Synthesis Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced Insulin LevelsBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced White Adipose Tissue WeightBeneficial
Large
Lactobacillus gasseri KS-13Enhanced GLUT4 ExpressionBeneficial
Moderate
Lactobacillus gasseri KS-13Increased Liver Fatty Acid Oxidation Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Body WeightBeneficial
Large
Lactobacillus gasseri KS-13Reduced Fatty Acid Synthesis-Related Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Insulin LevelsBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced White Adipose Tissue WeightBeneficial
Large
Lactobacillus gasseri LG-36Increased Fatty Acid OxidationBeneficial
Large
Lactobacillus gasseri LG-36Increased GLUT4 ExpressionBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Adipose Tissue WeightBeneficial
Large
Lactobacillus gasseri LG-36Reduced Body WeightBeneficial
Large
Lactobacillus gasseri LG-36Reduced Insulin LevelsBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Enhanced Fatty Acid Oxidation Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri LQ-36Enhanced GLUT4 ExpressionBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Body WeightBeneficial
Large
Lactobacillus gasseri LQ-36Reduced Fatty Acid Synthesis Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Insulin LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced White Adipose Tissue WeightBeneficial
Large
Lactobacillus gasseri SD-5585Enhanced GLUT4 ExpressionBeneficial
Moderate
Lactobacillus gasseri SD-5585Increased Liver Fatty Acid Oxidation Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Body WeightBeneficial
Large
Lactobacillus gasseri SD-5585Reduced Fatty Acid Synthesis-Related Gene ExpressionBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Insulin LevelsBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced White Adipose Tissue WeightBeneficial
Large
Back to top