Anti-obesity properties of the strain Bifidobacterium animalis subsp. lactis CECT 8145 in Zücker fatty rats.
- 2018-06-15
- Beneficial Microbes 9(4)
- N. L. Carreras
- P. Martorell
- E. Chenoll
- S. Genovés
- Daniel Ramón
- A. Aleixandre
- PubMed: 29695181
- DOI: 10.3920/BM2017.0141
Abstract
We evaluated the effect of oral administration of Bifidobacterium animalis subsp. lactis CECT 8145 strain in Zücker fatty rats. The Zücker fatty rats were randomly divided into two groups (n=10 each) and administered either B. animalis subsp. lactis CECT 8145 (1010 cfu/day) suspended in skim milk, or skim milk alone (control group). Each treatment was administered in drinking bottles from week 5 until week 17 of age. A lean Zücker rat group (standard group) was included to provide normal values for the Zücker strain. This group was administered skim milk in the drinking bottle for the same experimental period as Zücker fatty rats. Body weight gain was greater in the fatty control group than in the fatty rats treated daily with B. animalis subsp. lactis CECT 8145. Furthermore, dry and liquid food intake significantly decreased in the treated Zücker fatty group and these rats also showed decreased plasma ghrelin levels as compared with the Zücker fatty control group. B. animalis subsp. lactis CECT 8145 intake also decreased plasma tumour necrosis factor-α (a proinflammatory cytokine) and plasma malondialdehyde (a biomarker of oxidative stress). Moreover, the ratio plasma total cholesterol/plasma cholesterol transported by high-density lipoproteins, considered as an index for cardiovascular disease, also significantly decreased in the Zücker fatty rats treated with B. animalis subsp. lactis CECT 8145. By contrast, this bacterial strain significantly increased plasma adiponectin (an insulin-sensitising adipokine), but did not produce significant effects on triglyceride levels or glucose metabolism biomarkers. Although further research is required to confirm B. animalis subsp. lactis CECT 8145 is an efficient anti-obesity treatment in humans, the results obtained in this study are promising and point to the health and anti-obesity properties of this bacterial strain.
Keywords: Bifidobacterium spp.; cholesterol; ghrelin; glucose; obesity.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Total Cholesterol to HDL Cholesterol Ratio | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Improved Cholesterol Profile | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Serum Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Weight Gain | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Incidence of Cardiovascular Disease | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Plasma Tumor Necrosis Factor-α Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Serum Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Cardiovascular Dysfunction | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Plasma Tumor Necrosis Factor-α Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Improved Cardiovascular Health | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced TNF-α Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Improved Cardiovascular Health | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced TNF-α Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Improved Cardiovascular Health | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Plasma Malondialdehyde Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Total Cholesterol to HDL Cholesterol Ratio | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Improved Cardiovascular Health | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Increased Adiponectin Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | No Change in Serum Triglycerides | Neutral | Small |
| Bifidobacterium animalis subsp. lactis VK2 | No Significant Effect on Glucose Metabolism | Neutral | Small |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Body Weight | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Food Intake | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Inflammatory Markers | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Plasma Ghrelin Levels | Beneficial | Moderate |