Skip to main content

Anti-obesity properties of the strain Bifidobacterium animalis subsp. lactis CECT 8145 in Zücker fatty rats.

  • 2018-06-15
  • Beneficial Microbes 9(4)
    • N. L. Carreras
    • P. Martorell
    • E. Chenoll
    • S. Genovés
    • Daniel Ramón
    • A. Aleixandre

Abstract

We evaluated the effect of oral administration of Bifidobacterium animalis subsp. lactis CECT 8145 strain in Zücker fatty rats. The Zücker fatty rats were randomly divided into two groups (n=10 each) and administered either B. animalis subsp. lactis CECT 8145 (1010 cfu/day) suspended in skim milk, or skim milk alone (control group). Each treatment was administered in drinking bottles from week 5 until week 17 of age. A lean Zücker rat group (standard group) was included to provide normal values for the Zücker strain. This group was administered skim milk in the drinking bottle for the same experimental period as Zücker fatty rats. Body weight gain was greater in the fatty control group than in the fatty rats treated daily with B. animalis subsp. lactis CECT 8145. Furthermore, dry and liquid food intake significantly decreased in the treated Zücker fatty group and these rats also showed decreased plasma ghrelin levels as compared with the Zücker fatty control group. B. animalis subsp. lactis CECT 8145 intake also decreased plasma tumour necrosis factor-α (a proinflammatory cytokine) and plasma malondialdehyde (a biomarker of oxidative stress). Moreover, the ratio plasma total cholesterol/plasma cholesterol transported by high-density lipoproteins, considered as an index for cardiovascular disease, also significantly decreased in the Zücker fatty rats treated with B. animalis subsp. lactis CECT 8145. By contrast, this bacterial strain significantly increased plasma adiponectin (an insulin-sensitising adipokine), but did not produce significant effects on triglyceride levels or glucose metabolism biomarkers. Although further research is required to confirm B. animalis subsp. lactis CECT 8145 is an efficient anti-obesity treatment in humans, the results obtained in this study are promising and point to the health and anti-obesity properties of this bacterial strain.

Keywords: Bifidobacterium spp.; cholesterol; ghrelin; glucose; obesity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisIncreased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalisReduced Body WeightBeneficial
Large
Bifidobacterium animalisReduced Food IntakeBeneficial
Moderate
Bifidobacterium animalisReduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalisReduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalisReduced Total Cholesterol to HDL Cholesterol RatioBeneficial
Moderate
Bifidobacterium animalisReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium animalis subsp. lactisImproved Cholesterol ProfileBeneficial
Moderate
Bifidobacterium animalis subsp. lactisIncreased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Serum Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Weight GainBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Incidence of Cardiovascular DiseaseBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Plasma Tumor Necrosis Factor-α LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Serum Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis BLC1Reduced Cardiovascular DysfunctionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Plasma Tumor Necrosis Factor-α LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Improved Cardiovascular HealthBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis BS-01Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced TNF-α LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Improved Cardiovascular HealthBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced TNF-α LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Improved Cardiovascular HealthBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis HN019Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Plasma Ghrelin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Plasma Malondialdehyde LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Total Cholesterol to HDL Cholesterol RatioBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Improved Cardiovascular HealthBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Increased Adiponectin LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2No Change in Serum TriglyceridesNeutral
Small
Bifidobacterium animalis subsp. lactis VK2No Significant Effect on Glucose MetabolismNeutral
Small
Bifidobacterium animalis subsp. lactis VK2Reduced Body WeightBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Reduced Food IntakeBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Hepatic Oxidative StressBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Inflammatory MarkersBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Plasma Ghrelin LevelsBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.