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Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk.

  • 2019-09
  • Food Research International 123
    • M. R. Riaz Rajoka
    • Haobin Zhao
    • H. Mehwish
    • Nan Li
    • Yao Lu
    • Ziyang Lian
    • D. Shao
    • M. Jin
    • Qi Li
    • Liqing Zhao
    • Junling Shi

Abstract

Lactobacilli rhamnosus has been characterized as a probiotic and plays an important role in human health by stimulating the supplement of nutrients, preventing the colonization of pathogens, and influencing the immune system. This study investigated the anticancer activity of the three Lactobacillus rhamnosus strains SHA111, SHA112, and SHA113 isolated from human breast milk. The cell-free supernatant of a liquid culture of the three strains showed excellent antioxidant activities against DPPH free radicals, superoxide anion radicals, and hydroxyl radicals; furthermore, significant anticancer activity was found on cervix cancer cells (HeLa) via cytotoxicity and induction of apoptosis. RT-qPCR and western blot analysis showed the induction of apoptosis was achieved via the up-regulation of BAD, BAX, Caspase3, Caspase8, Caspase9, and down-regulation of BCL-2 genes in HeLa cells. The results suggest that these strains have potential anticancer capability.

Keywords: Antioxidant; Antitumor; Apoptosis; Lactobacillus; Probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosusIncreased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosusIncreased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus DSM33560Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus DSM33560Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus DSM 6594Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus DSM 6594Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus HA-11Cytotoxicity Against Cervical Cancer CellsBeneficial
Large
Lactobacillus rhamnosus HA-11Increased Apoptosis in Cancer CellsBeneficial
Large
Lactobacillus rhamnosus HA-111Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus HA-111Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus HA-114Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus HA-114Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus LBV96Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus LBV96Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus LBV96Increased Apoptosis in Cancer CellsBeneficial
Large
Lactobacillus rhamnosus LR06Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus LR06Increased Anti-Tumor ActivityBeneficial
Large
Lactobacillus rhamnosus LR06Increased Apoptosis in Cancer CellsBeneficial
Large
Lactobacillus rhamnosus MAK79L08RIncreased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus MAK79L08RInduced ApoptosisBeneficial
Large
Lactobacillus rhamnosus MAK79L08RReduced Cancer Cell ViabilityBeneficial
Large
Lactobacillus rhamnosus PXN 54Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus PXN 54Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus PXN 54Induced ApoptosisBeneficial
Large
Lactobacillus rhamnosus R0011Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus R0011Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus R0011Induced ApoptosisBeneficial
Large
Lactobacillus rhamnosus R0343NDIncreased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus R0343NDIncreased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus R0343NDInduced ApoptosisBeneficial
Large
Lactobacillus rhamnosus UALr-18Increased Cancer Cell ApoptosisBeneficial
Large
Lactobacillus rhamnosus UALr-18Reduced Cancer Cell ViabilityBeneficial
Large
Lactobacillus rhamnosus VPro 11Increased Anticancer ActivityBeneficial
Large
Lactobacillus rhamnosus VPro 11Increased Antioxidant ActivityBeneficial
Large
Lactobacillus rhamnosus VPro 11Induced ApoptosisBeneficial
Large
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