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Antidepressant Effects of Bifidobacterium animalis CP-9 in LPS-Induced Depressive Mice.

  • 2025-12-12
  • Foods (Basel, Switzerland) 14(24)
    • Shenglan Su
    • Ziyi Jiang
    • Fang He
    • Cailing Chen
    • Yuping Yang
    • Liang Dong
    • Youhua Ren
    • Ke Li
    • Zongjun Li
    • Yuanliang Wang

Study Design

Population
mice
Methods
An acute depression model was established in mice using lipopolysaccharide (LPS), and the potential antidepressant effects and mechanisms of Bifidobacterium animalis CP-9 were investigated. Intervention with CP-9 at a dose of 10^8 CFU/mL.
Depression is a common mood disorder, and growing evidence has revealed the critical role of gut microbiota in its onset and progression. The gut-brain axis, which connects the central nervous system and intestinal microecology, offers new strategies for depression intervention. In this study, an acute depression model was established in mice using lipopolysaccharide (LPS), and the potential antidepressant effects and mechanisms of Bifidobacterium animalis CP-9 were investigated. The results indicated that CP-9 may exert antidepressant effects through multiple pathways, including modulation of peripheral and central inflammatory responses, restoration of gut microbiota balance, enhancement of short-chain fatty acid (SCFA) production, and regulation of neurotransmitter metabolism such as γ-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT). Notably, intervention with CP-9 at a dose of 108 CFU/mL significantly alleviated depressive-like behaviors in mice, suggesting its promising potential in the prevention and treatment of mood disorders.

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