Antidepressant Effects of Bifidobacterium animalis CP-9 in LPS-Induced Depressive Mice.
- 2025-12-12
- Foods (Basel, Switzerland) 14(24)
- PubMed: 41464995
- DOI: 10.3390/foods14244289
Study Design
- Population
- mice
- Methods
- An acute depression model was established in mice using lipopolysaccharide (LPS), and the potential antidepressant effects and mechanisms of Bifidobacterium animalis CP-9 were investigated. Intervention with CP-9 at a dose of 10^8 CFU/mL.
Depression is a common mood disorder, and growing evidence has revealed the critical role of gut microbiota in its onset and progression. The gut-brain axis, which connects the central nervous system and intestinal microecology, offers new strategies for depression intervention. In this study, an acute depression model was established in mice using lipopolysaccharide (LPS), and the potential antidepressant effects and mechanisms of Bifidobacterium animalis CP-9 were investigated. The results indicated that CP-9 may exert antidepressant effects through multiple pathways, including modulation of peripheral and central inflammatory responses, restoration of gut microbiota balance, enhancement of short-chain fatty acid (SCFA) production, and regulation of neurotransmitter metabolism such as γ-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT). Notably, intervention with CP-9 at a dose of 108 CFU/mL significantly alleviated depressive-like behaviors in mice, suggesting its promising potential in the prevention and treatment of mood disorders.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Bifidobacterium animalis | — | Improved Gut Microbiota Balance | Beneficial | Moderate | View sourcerestoration of gut microbiota balance |
| Bifidobacterium animalis | — | Improved Neurotransmitter Metabolism | Beneficial | Moderate | View sourceregulation of neurotransmitter metabolism such as γ-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT) |
| Bifidobacterium animalis | — | Increased Short-Chain Fatty Acid Production | Beneficial | Moderate | View sourceenhancement of short-chain fatty acid (SCFA) production |
| Bifidobacterium animalis | — | Reduced Depression-like Behavior | Beneficial | Moderate | View sourceintervention with CP-9 at a dose of 10^8 CFU/mL significantly alleviated depressive-like behaviors in mice |
| Bifidobacterium animalis | — | Reduced Inflammatory Response | Beneficial | Moderate | View sourceCP-9 may exert antidepressant effects through multiple pathways, including modulation of peripheral and central inflammatory responses |