Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.
- 2015-09-02
- Molecular Nutrition & Food Research 59(11)
- M. Gómez-Guzmán
- M. Toral
- M. Romero
- R. Jiménez
- P. Galindo
- M. Sánchez
- M. J. Zarzuelo
- M. Olivares
- J. Gálvez
- J. Duarte
- PubMed: 26255877
- DOI: 10.1002/mnfr.201500290
Abstract
Scope: The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus L. gasseri CECT5714 (LC9) (1:1) in spontaneously hypertensive rats (SHR) were evaluated.
Methods and results: Ten Wistar Kyoto rats (WKY) and 30 SHR were randomly assigned to four groups (n = 10): a control WKY group, a control SHR groups, an SHR group treated with LC40, and an SHR treated with K8/LC9 group for 5 weeks (at a dose of 3.3 × 10(10) colony-forming units/day in drinking water). Long-term administration of probiotics reduced systolic blood pressure. The consumption of K8/LC9 mixture significantly reduced the cardiac and renal hypertrophy. Both groups of probiotics reversed the impaired aortic endothelium-dependent relaxation to acetylcholine observed in SHR. They also abolished the increased aortic superoxide levels by reducing the increased toll-like receptor-4 mRNA levels and NADPH oxidase activity found in SHR. K8/LC9 consumption also increased endothelial nitric oxide synthase phosphorylation. Probiotic treatments induced a change in the cecum microbiota of SHR, with higher counts of the Lactobacillus spp. cluster, and lower counts of Bacteriodes spp. and Clostridium spp.
Conclusion: Probiotics exert cardiovascular protective effects in genetic hypertension related to the improvement of vascular pro-oxidative and pro-inflammatory status.
Keywords: Endothelial dysfunction; Gut microbiota; Hypertension; Probiotic bacteria; SHR.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus fermentum CECT5716 | Change in Cecum Microbiota Composition | Neutral | Moderate |
| Lactobacillus fermentum CECT5716 | Improved Vascular Endothelial Function | Beneficial | Moderate |
| Lactobacillus fermentum CECT5716 | Reduced Aortic Superoxide Levels | Beneficial | Moderate |
| Lactobacillus fermentum CECT5716 | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Altered Cecum Microbiota Composition | Beneficial | Large |
| Lactobacillus gasseri LQ-36 | Improved Vascular Endothelial Function | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Increased Endothelial Nitric Oxide Synthase Activity | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced Aortic Superoxide Levels | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced Systolic Blood Pressure | Beneficial | Moderate |