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Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.

  • 2015-09-02
  • Molecular Nutrition & Food Research 59(11)
    • M. Gómez-Guzmán
    • M. Toral
    • M. Romero
    • R. Jiménez
    • P. Galindo
    • M. Sánchez
    • M. J. Zarzuelo
    • M. Olivares
    • J. Gálvez
    • J. Duarte


Scope: The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus L. gasseri CECT5714 (LC9) (1:1) in spontaneously hypertensive rats (SHR) were evaluated.

Methods and results: Ten Wistar Kyoto rats (WKY) and 30 SHR were randomly assigned to four groups (n = 10): a control WKY group, a control SHR groups, an SHR group treated with LC40, and an SHR treated with K8/LC9 group for 5 weeks (at a dose of 3.3 × 10(10) colony-forming units/day in drinking water). Long-term administration of probiotics reduced systolic blood pressure. The consumption of K8/LC9 mixture significantly reduced the cardiac and renal hypertrophy. Both groups of probiotics reversed the impaired aortic endothelium-dependent relaxation to acetylcholine observed in SHR. They also abolished the increased aortic superoxide levels by reducing the increased toll-like receptor-4 mRNA levels and NADPH oxidase activity found in SHR. K8/LC9 consumption also increased endothelial nitric oxide synthase phosphorylation. Probiotic treatments induced a change in the cecum microbiota of SHR, with higher counts of the Lactobacillus spp. cluster, and lower counts of Bacteriodes spp. and Clostridium spp.

Conclusion: Probiotics exert cardiovascular protective effects in genetic hypertension related to the improvement of vascular pro-oxidative and pro-inflammatory status.

Keywords: Endothelial dysfunction; Gut microbiota; Hypertension; Probiotic bacteria; SHR.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentum CECT5716Change in Cecum Microbiota CompositionNeutral
Lactobacillus fermentum CECT5716Improved Vascular Endothelial FunctionBeneficial
Lactobacillus fermentum CECT5716Reduced Aortic Superoxide LevelsBeneficial
Lactobacillus fermentum CECT5716Reduced Systolic Blood PressureBeneficial
Lactobacillus gasseri LQ-36Altered Cecum Microbiota CompositionBeneficial
Lactobacillus gasseri LQ-36Improved Vascular Endothelial FunctionBeneficial
Lactobacillus gasseri LQ-36Increased Endothelial Nitric Oxide Synthase ActivityBeneficial
Lactobacillus gasseri LQ-36Reduced Aortic Superoxide LevelsBeneficial
Lactobacillus gasseri LQ-36Reduced Systolic Blood PressureBeneficial

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