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Antimicrobial potential of four Lactobacillus strains isolated from breast milk

  • 2006-07
  • Journal of Applied Microbiology 101(1)
    • M. Olivares
    • M. Díaz-Ropero
    • R. Martín
    • J. M. Rodríguez
    • J. Xaus

Abstract

Aims: The antimicrobial potential of four lactobacilli (Lactobacillus salivarius CECT5713, Lactobacillus gasseri CECT5714, L. gasseri CECT5715 and Lactobacillus fermentum CECT5716), isolated from fresh human breast milk, was evaluated in this study and compared with Lactobacillus coryniformis CECT5711, a reuterin-producing strain isolated from an artisan goat's cheese.

Methods and results: Agar diffusion tests, competitive adhesion assays and mucin expression assays were carried out in order to value the antibacterial properties of the lactobacilli strains. The antibacterial capability of the strains was tested in vivo by using a murine infection model with Salmonella choleraesuis. The results revealed that all the strains studied, displayed antibacterial properties against pathogenic bacteria. However, the antibacterial potential varied among the lactobacilli tested and, in fact, L. salivarius CECT5713 showed not only the best in vitro antibacterial activity, but also the highest protective effect against a Salmonella strain in the murine infection model.

Conclusion: The four breast-milk lactobacilli, and particularly L. salivarius CECT5713, possess potent antibacterial activities that result in a higher protection against S. choleraesuis CECT4155 in a mouse infection model.

Significance and impact of the study: These results suggest that lactobacilli from breast milk could contribute to an anti-infective protection in neonates and would be excellent candidates for the development of infant probiotic products.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentum CECT5716Enhanced Antibacterial EffectBeneficial
Moderate
Lactobacillus fermentum CECT5716Enhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus salivarius VPro 15Enhanced Protection Against InfectionBeneficial
Large
Lactobacillus salivarius VPro 15Improved Antibacterial ActivityBeneficial
Large
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