Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens.

2023-01-30
Antibiotics (Basel, Switzerland) 12(2)

PubMed: 36830185
DOI: 10.3390/antibiotics12020274

Study Design

Type: Review
Methods: This review provides insights into the evolution and the mechanisms of AMR. Additionally, it discusses alternative approaches that might be used to control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, and nanoparticles.

Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use of antibiotics in humans and animals has resulted in the emergence of antibiotic-resistant bacteria. The dissemination of these strains and their resistant determinants could endanger antibiotic efficacy. Therefore, there is an urgent need to identify and develop novel strategies to combat antibiotic resistance. This review provides insights into the evolution and the mechanisms of AMR. Additionally, it discusses alternative approaches that might be used to control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, and nanoparticles.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bacillus clausii SC-109	—	Improved Gastrointestinal Function	Beneficial	Moderate	View source Consumption of Bacillus clausii SC-109 was associated with improved gastrointestinal function and relief of digestive discomfort in the study abstract.