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Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats

  • 2011-07-12
  • Lipids in Health and Disease 10(1)
    • H. An
    • Shin‐Young Park
    • Do Kyung Lee
    • Jung Rae Kim
    • M. Cha
    • S. Lee
    • H. Lim
    • K. Kim
    • N. Ha

Abstract

Background: Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats.

Methods: Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 108 ~ 109 CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured.

Results: Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts.

Conclusion: These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium bifidum SD-5857Increased Fecal Lactobacillus CountBeneficial
Large
Bifidobacterium bifidum SD-5857Reduced Blood Leptin LevelsBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Blood Serum CholesterolBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Body WeightBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Fat WeightBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Glucose LevelsBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Harmful Enzyme ActivityBeneficial
Moderate
Bifidobacterium bifidum SD-5857Reduced Triglyceride LevelsBeneficial
Moderate
Bifidobacterium longum SP54Improved Blood Glucose LevelsBeneficial
Moderate
Bifidobacterium longum SP54Improved Lipid ProfileBeneficial
Moderate
Bifidobacterium longum SP54Improved Liver FunctionBeneficial
Moderate
Bifidobacterium longum SP54Increased Fecal Lactic Acid Bacteria CountsBeneficial
Large
Bifidobacterium longum SP54Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum SP54Reduced Harmful Enzyme ActivityBeneficial
Moderate
Bifidobacterium longum SP54Reduced Leptin LevelsBeneficial
Moderate

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