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Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial

  • 2016-03-09
  • European Journal of Clinical Nutrition 70(5)
    • Fumiko Higashikawa
    • M. Noda
    • Tomokazu Awaya
    • Narandalai Danshiitsoodol
    • Y. Matoba
    • T. Kumagai
    • Masanori Sugiyama

Abstract

Background/objectives: The population of the obese is increasing worldwide. Prevention and improvement of obesity are indispensable for decreasing the risk of metabolic disorders. We have recently shown that obesity and fatty liver are reduced by a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28), in high-fat diet-induced obese mice. The aim of the present clinical study is to prove that LP28 is effective for reducing body fat and body weight, as shown in the experiment using mice.

Subjects/methods: The clinical trial was carried out as a double-blind, randomized, placebo-controlled study comprising 62 subjects (20-70 years of age, BMI 25-30 kg/m(2)). These subjects were randomly assigned to three groups that received living LP28, heat-killed LP28 or a placebo powder, administered orally once a day for 12 weeks.

Results: Heat-killed LP28 reduced BMI (0.45 kg/m(2), 95% CI (0.04, 0.86), P=0.035), body fat percentage (1.11%, (0.39, 1.82), P=0.002), body fat mass (1.17 kg (0.43, 1.92), P=0.004) and waist circumference (2.84 cm (0.74, 4.93), P=0.009) when compared with a placebo group. Fasting plasma glucose, HbA1c, fasting insulin, HOMA-IR and serum lipids levels did not change by either living LP28 or heat-killed LP28 intake.

Conclusions: Heat-killed LP28 displays an antiobesity effect that reduces BMI, body fat and waist circumference, suggesting that the plant-derived lactic acid bacterium LP28 would be a promising preventive of metabolic syndrome.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Pediococcus pentosaceus KABP™-041Reduced Body Fat MassBeneficial
Moderate
Pediococcus pentosaceus KABP™-041Reduced Body Fat PercentageBeneficial
Moderate
Pediococcus pentosaceus KABP™-041Reduced Body Mass IndexBeneficial
Moderate
Pediococcus pentosaceus KABP™-041Reduced Waist CircumferenceBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Body Fat MassBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Body Fat PercentageBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Body Mass IndexBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Waist CircumferenceBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PStable Glucose Metabolism MarkersNeutral
Small
Pediococcus pentosaceus PP06Reduced Body Fat MassBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Body Fat PercentageBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Body Mass IndexBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Waist CircumferenceBeneficial
Moderate

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