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Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

  • 2010-08-23
  • Bioscience, Biotechnology, and Biochemistry 74(8)
    • S. Kondo
    • J. Xiao
    • T. Satoh
    • T. Odamaki
    • Sachiko Takahashi
    • H. Sugahara
    • T. Yaeshima
    • K. Iwatsuki
    • A. Kamei
    • K. Abe

Abstract

The aim of the present study was to evaluate the anti-obesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve BR03Improved Fasting Glucose LevelsBeneficial
Moderate
Bifidobacterium breve BR03Improved Fat Metabolism Gene ExpressionBeneficial
Moderate
Bifidobacterium breve BR03Improved Insulin LevelsBeneficial
Large
Bifidobacterium breve BR03Improved Insulin SensitivityBeneficial
Large
Bifidobacterium breve BR03Improved Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium breve BR03Reduced Body Weight AccumulationBeneficial
Large
Bifidobacterium breve BR03Reduced Epididymal Adipose TissueBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved Cholesterol LevelsBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved Fasting Glucose LevelsBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved Fat Metabolism Gene ExpressionBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved Insulin SensitivityBeneficial
Large
Bifidobacterium breve MAK40B22BIncreased Bifidobacterial PopulationBeneficial
Large
Bifidobacterium breve MAK40B22BReduced Epididymal Adipose TissueBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Weight GainBeneficial
Moderate
Bifidobacterium breve VPro 52Improved Fasting Glucose LevelsBeneficial
Moderate
Bifidobacterium breve VPro 52Improved Fat Metabolism Gene ExpressionBeneficial
Moderate
Bifidobacterium breve VPro 52Improved Insulin SensitivityBeneficial
Large
Bifidobacterium breve VPro 52Improved Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium breve VPro 52Reduced Body Weight AccumulationBeneficial
Large

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