Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

2010-08-23
Bioscience, Biotechnology, and Biochemistry 74(8)
- S. Kondo
- J. Xiao
- T. Satoh
- T. Odamaki
- Sachiko Takahashi
- H. Sugahara
- T. Yaeshima
- K. Iwatsuki
- A. Kamei
- K. Abe

PubMed: 20699581
DOI: 10.1271/bbb.100267

Study Design

Type: Clinical Trial
Population: Obese mice induced by a high-fat diet
Methods: In vivo experiment with mice.

Highly Cited
Animal Study

Abstract

The aim of the present study was to evaluate the anti-obesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.

Research Insights

Bifidobacterium breve MAK40B22B→Improved Cholesterol Levels
Improved the serum levels of total cholesterol.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Improved Fasting Glucose Levels
B. breve B-3 supplementation... improved the serum levels of... fasting glucose.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Improved Insulin Sensitivity
B. breve B-3 supplementation... improved the serum levels of... insulin.
Effect
Beneficial
Effect size
Large
Bifidobacterium breve MAK40B22B→Increased Bifidobacterial Population
The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration.
Effect
Beneficial
Effect size
Large
Bifidobacterium breve MAK40B22B→Reduced Epididymal Adipose Tissue
B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Reduced Weight Gain
B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve VPro 52→Improved Fasting Glucose Levels
B. breve B-3 supplementation... improved the serum levels of... fasting glucose.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve VPro 52→Improved Insulin Sensitivity
B. breve B-3 supplementation... improved the serum levels of... insulin.
Effect
Beneficial
Effect size
Large
Bifidobacterium breve VPro 52→Improved Total Cholesterol Levels
B. breve B-3 supplementation... improved the serum levels of total cholesterol.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve VPro 52→Reduced Body Weight Accumulation
B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat.
Effect
Beneficial
Effect size
Large