Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity
- 2010-08-23
- Bioscience, Biotechnology, and Biochemistry 74(8)
- S. Kondo
- J. Xiao
- T. Satoh
- T. Odamaki
- Sachiko Takahashi
- H. Sugahara
- T. Yaeshima
- K. Iwatsuki
- A. Kamei
- K. Abe
- PubMed: 20699581
- DOI: 10.1271/bbb.100267
Abstract
The aim of the present study was to evaluate the anti-obesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium breve BR03 | Improved Fasting Glucose Levels | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Improved Fat Metabolism Gene Expression | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Improved Insulin Levels | Beneficial | Large |
| Bifidobacterium breve BR03 | Improved Insulin Sensitivity | Beneficial | Large |
| Bifidobacterium breve BR03 | Improved Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium breve BR03 | Reduced Body Weight Accumulation | Beneficial | Large |
| Bifidobacterium breve BR03 | Reduced Epididymal Adipose Tissue | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Improved Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Improved Fasting Glucose Levels | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Improved Fat Metabolism Gene Expression | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Improved Insulin Sensitivity | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Increased Bifidobacterial Population | Beneficial | Large |
| Bifidobacterium breve MAK40B22B | Reduced Epididymal Adipose Tissue | Beneficial | Moderate |
| Bifidobacterium breve MAK40B22B | Reduced Weight Gain | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Improved Fasting Glucose Levels | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Improved Fat Metabolism Gene Expression | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Improved Insulin Sensitivity | Beneficial | Large |
| Bifidobacterium breve VPro 52 | Improved Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium breve VPro 52 | Reduced Body Weight Accumulation | Beneficial | Large |