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Abstract

Lactobacillus plantarum KU15149 was demonstrated to have probiotic behavior and functions, including antioxidant and anti-inflammatory activity. L. plantarum KU15149 obtained from homemade diced-radish kimchi has a high survival rate under artificial gastric acid (pH 2.5, 0.3% pepsin) and bile salt (0.3% oxgall) conditions. However, L. plantarum KU15149 did not produce β-glucuronidase, which is known to be a carcinogenic enzyme with resistance to several antibiotics, such as gentamycin, kanamycin, streptomycin, tetracycline, and ciprofloxacin. L. plantarum KU15149 strongly adhered to HT-29 cells and had high antioxidant activity in terms of 2,2-diphenyl- 1-picrylhydrazyl (DPPH) free radical-scavenging and β-carotene bleaching assays. L. plantarum KU15149 also exhibited a pronounced inhibition of nitric oxide (NO) production, along with expression of nitric oxide synthase (iNOS) and cyclooxygenase -2 (COX-2) as well as proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, when RAW 264.7 cells were stimulated with LPS. Therefore, L. plantarum KU15149 exhibited pharmaceutical functionality as a potential probiotic.

Keywords: Lactobacillus plantarum; Probiotics; anti-inflammatory; antioxidant; kimchi.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum 14DAbsence of Antibiotic ResistanceBeneficial
Large
Lactobacillus plantarum 14DImproved Intestinal Cell AdhesionBeneficial
Moderate
Lactobacillus plantarum 14DImproved Probiotic FunctionalityBeneficial
Moderate
Lactobacillus plantarum 14DIncreased Antioxidant ActivityBeneficial
Large
Lactobacillus plantarum 14DIncreased Gastric Survival RateBeneficial
Moderate
Lactobacillus plantarum 14DReduced Inflammatory ResponseBeneficial
Large
Lactobacillus plantarum LP09Enhanced Antioxidant ActivityBeneficial
Large
Lactobacillus plantarum LP09Reduced Inflammatory MarkersBeneficial
Large
Lactobacillus plantarum SD-5209Increased Antioxidant ActivityBeneficial
Large
Lactobacillus plantarum SD-5209Reduced Inflammatory MarkersBeneficial
Large
Lactobacillus plantarum SD-5209Reduced Intestinal Cell AdhesionBeneficial
Large
Lactobacillus plantarum SD-5209Reduced Production of Carcinogenic EnzymesBeneficial
Large

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