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Antioxidant, antihypertensive, and immunomodulatory activities of peptide fractions from fermented skim milk with Lactobacillus delbrueckii ssp. bulgaricus LB340.

  • 2011-01-10
  • Journal of Dairy Research 78(1)
    • Bingjun Qian
    • Meizi Xing
    • Lei Cui
    • Yun Deng
    • Yu‐Quan Xu
    • Min-Zhao Huang
    • Shaohui Zhang


The aim of this study was to evaluate the antioxidant, antihypertensive and immunomodulatory characteristics of skim milk fermented with Lactobacillus delbrueckii ssp. bulgaricus LB340. Supernatants obtained from the ferments after centrifugation were subjected to ultrafiltration and yielded four peptidic fractions of 10-5 kDa, 5-3 kDa, 3-1 kDa, and <1·0 kDa. Peptides in 5-3 kDa range exhibited a good antioxidant activity. The peptides (<1·0 k) was applied to Superdex-30 G column fractionation and produced six fractions (F1-6). Fraction F2 presented the highest angiotensin I-converting enzyme inhibition activity with IC50 of 67·71 ± 7·62 mg/ml. Moreover, fraction F6, which displayed a good immunomodulatory activity, had a positive effect on murine spleen lymphocyte proliferation with Stimulation Index of 0·729 ± 0·123. The present data showed the potential of the milk fermented with Lactobacillus delbrueckii ssp. bulgaricus LB340 as a functional food, however, further research is needed to evaluate the biofunctional activity of this fermentation product in vivo using model animal.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus bulgaricus LB42Improved ImmunomodulationBeneficial
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Lactobacillus bulgaricus LB42Reduced HypertensionBeneficial
Lactobacillus bulgaricus Lb-87Improved ImmunomodulationBeneficial
Lactobacillus bulgaricus Lb-87Increased Antioxidant ActivityBeneficial
Lactobacillus bulgaricus Lb-87Reduced Angiotensin I-Converting Enzyme ActivityBeneficial
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