Application of Lactobaillus salivarius WB21 to the Oral Care of Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Comparative Study
- 2022-09-13
- Life 12(9)
- Satoko Kijima
- N. Suzuki
- T. Hanioka
- M. Yoneda
- Kazunari Tanabe
- T. Hirofuji
- PubMed: 36143458
- DOI: 10.3390/life12091422
Abstract
Objective: A randomized, double-blind, placebo-controlled crossover comparative study was conducted in a healthy older population to assess the usefulness of Lactobacillus salivarius WB21 (WB21) ingestion for oral self-care.
Methods: The study population included 33 healthy older individuals who were randomly divided into two groups (A and B). Group A consumed WB21 tablets during the first two months and placebo tablets during the following two months. Group B consumed placebo tablets during the first two months and WB21 tablets during the following two months. Before and after ingestion, oral examination, mouth odor test, and saliva collection were performed a total of four times. In addition, health conditions were obtained from a questionnaire survey at the study's midpoint.
Results: Two people in group A and one person in group B dropped out of the study. Thus, 15 people in group A and 15 people in group B were included in the analysis. Over two months of WB21 ingestion, salivary secretory IgA increased significantly (p = 0.047) and tongue coating score decreased significantly (p = 0.013). The plaque index, bleeding on probing, and mouth odor levels (H2S and CH3SH concentrations) did not change. During the 6-month study period, no caries, deterioration of periodontitis, or changes in oral health or systemic subjective symptoms were observed.
Conclusion: Continuous ingestion of WB21-containing tablets may promote self-care of the teeth and mouths of healthy older adults.
Trial registration: R000028335 (UMIN-CTR).
Keywords: Lactobacillus salivarius; older; self-care.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Lactobacillus Salivarius | Increased Salivary sIgA Levels | Beneficial | Moderate |
Lactobacillus Salivarius | Reduced Tongue Coating Score | Beneficial | Moderate |