Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence.
- 2025-10
- Diabetes & metabolic syndrome 19(10)
- Ali Jafari
- Mohammad Amin Karimi
- Mahsa Mahmoudinezhad
- Fatemeh Razavi
- Helia Mardani
- Vali Musazadeh
- PubMed: 41270328
- DOI: 10.1016/j.dsx.2025.103328
Study Design
- Type
- Meta-Analysis
- Population
- adults
- Methods
- Comprehensive literature search of PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials up to September 2024
Background and aims
This systematic review and meta-analysis was conducted to evaluate the effects of artichoke supplementation on cardiometabolic health markers in adults.Methods
A comprehensive literature search of PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials was conducted up to September 2024.Results
Artichoke supplementation significantly reduced body mass index (WMD = -0.51 kg/m2, 95 % CI: 0.93 to -0.09) and waist circumference (WMD = -1.21 cm, 95 % CI: 2.24 to -0.17), while its effects on body weight and hip circumference were not statistically significant. Blood pressure outcomes revealed significant reductions in both systolic (WMD = -2.49 mmHg, 95 % CI: 4.33 to -0.65) and diastolic (WMD = -1.53 mmHg, 95 % CI: 3.01 to -0.05) pressures. Significant lipid profile improvements were observed in total cholesterol (WMD = -12.29 mg/dL, 95 % CI: 19.92 to -4.65), low-density lipoprotein cholesterol (WMD = -10.31 mg/dL, 95 % CI: 18.57 to -2.04), and triglycerides (WMD = -12.85 mg/dL, 95 % CI: 24.77 to -0.93), with no significant effect on high-density lipoprotein cholesterol. Regarding glycemic indices, insulin (WMD = -1.83 mU/L, 95 % CI: 3.33 to -0.32) and homeostatic model assessment for insulin resistance (WMD = -0.92, 95 % CI: 1.33 to -0.51) were significantly reduced, whereas fasting blood glucose and HbA1c were unaffected. Among liver function markers, alanine aminotransferase (WMD = -8.47 U/L, 95 % CI: 14.71 to -2.23) and alkaline phosphatase (WMD = -7.86 U/L, 95 % CI: 15.26 to -0.45) were significantly reduced, while aspartate aminotransferase showed a borderline non-significant effect. No significant change was observed in creatinine levels.Conclusion
Artichoke supplementation may offer modest but significant improvements in several cardiometabolic risk markers.Research Insights
insulin (WMD = -1.83 mU/L, 95 % CI: 3.33 to -0.32)
- Effect
- Beneficial
- Effect size
- Small
alanine aminotransferase (WMD = -8.47 U/L, 95 % CI: 14.71 to -2.23)
- Effect
- Beneficial
- Effect size
- Small
alkaline phosphatase (WMD = -7.86 U/L, 95 % CI: 15.26 to -0.45) were significantly reduced
- Effect
- Beneficial
- Effect size
- Small
Artichoke supplementation significantly reduced body mass index (WMD = -0.51 kg/m2, 95 % CI: 0.93 to -0.09)
- Effect
- Beneficial
- Effect size
- Small
diastolic (WMD = -1.53 mmHg, 95 % CI: 3.01 to -0.05) pressures
- Effect
- Beneficial
- Effect size
- Small
homeostatic model assessment for insulin resistance (WMD = -0.92, 95 % CI: 1.33 to -0.51) were significantly reduced
- Effect
- Beneficial
- Effect size
- Small
low-density lipoprotein cholesterol (WMD = -10.31 mg/dL, 95 % CI: 18.57 to -2.04)
- Effect
- Beneficial
- Effect size
- Small
significant reductions in both systolic (WMD = -2.49 mmHg, 95 % CI: 4.33 to -0.65) and diastolic (WMD = -1.53 mmHg, 95 % CI: 3.01 to -0.05) pressures
- Effect
- Beneficial
- Effect size
- Small
Significant lipid profile improvements were observed in total cholesterol (WMD = -12.29 mg/dL, 95 % CI: 19.92 to -4.65)
- Effect
- Beneficial
- Effect size
- Small
triglycerides (WMD = -12.85 mg/dL, 95 % CI: 24.77 to -0.93)
- Effect
- Beneficial
- Effect size
- Small
waist circumference (WMD = -1.21 cm, 95 % CI: 2.24 to -0.17)
- Effect
- Beneficial
- Effect size
- Small