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Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5.

  • 2016-12
  • Food Research International 90
    • C. S. Moura
    • P. Lollo
    • P. Morato
    • E. Esmerino
    • L. P. Margalho
    • V. A. Santos-Junior
    • P. T. Coimbra
    • L. Cappato
    • M. C. Silva
    • A. S. Garcia-Gomes
    • D. Granato
    • H. Bolini
    • A. Sant’Ana
    • A. Cruz
    • J. Amaya-Farfan

Abstract

The viability and survival of Lactobacillus acidophilus La5 under in vitro simulated gastrointestinal in probiotic dairy dessert was assessed. In addition, the effects of regular consumption of the dessert (5g/day) on the lipid profile, immune system, and antioxidant/biochemical status of Wistar rats were also evaluated after 2weeks of treatment. Adequate counts of L. acidophilus La-5 were observed regards the viability and gastrointestinal conditions. The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum. Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p>0.05) after 15days of treatment. Overall, the probiotic dairy dessert may be a viable alternative to enhance the blood lipid profile and could be used to improve the antioxidant defenses.

Keywords: Antioxidant defense; Dairy dessert; Immune system; Probiotic bacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusImproved Lipid ProfileBeneficial
Moderate
Lactobacillus acidophilusUnchanged Biochemical ParametersNeutral
Small
Lactobacillus acidophilus HA-122Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus HA-122Maintained Blood-Cell CountsNeutral
Small
Lactobacillus acidophilus HA-122Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus HA-122Stable Immune System ResponsesNeutral
Small
Lactobacillus acidophilus L-92Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus L-92Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus acidophilus L-92Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus LA-02Enhanced Antioxidant DefenseBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Lipid ProfileBeneficial
Moderate
Lactobacillus acidophilus LA1Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA1No Significant Changes in Immune ParametersNeutral
Small
Lactobacillus acidophilus LA1No Significant Effect on Liver EnzymesNeutral
Small
Lactobacillus acidophilus LA1Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus LA1Unchanged Antioxidant DefensesNeutral
Small
Lactobacillus acidophilus La-14Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus LA-5Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA-5Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus acidophilus LA-5Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus LA85Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus LA85No Change in Immune System ResponseNeutral
Small
Lactobacillus acidophilus LA85No Change in Liver EnzymesNeutral
Small
Lactobacillus acidophilus LA85Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus acidophilus LA85Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AImproved Lipid ProfileBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AUnchanged Biochemical ParametersNeutral
Small
Lactobacillus acidophilus NCIMB 30333Improved Lipid LevelsBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Unchanged Biochemical ParametersNeutral
Small
Lactobacillus acidophilus R0418Improved Lipid ProfileBeneficial
Moderate
Lactobacillus acidophilus SD-5212Improved HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus SD-5212Improved LDL CholesterolBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus SD-5212Stable Blood Cell CountsNeutral
Small
Lactobacillus acidophilus SD-5212Unchanged Liver Function MarkersNeutral
Small
Lactobacillus acidophilus UALa01Increased HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus acidophilus UALa01Maintained Albumin LevelsNeutral
Small
Lactobacillus acidophilus UALa01Maintained Total Protein LevelsNeutral
Small
Lactobacillus acidophilus UALa01Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus acidophilus UALa01Stable Alanine Aminotransferase LevelsNeutral
Small
Lactobacillus acidophilus UALa01Stable Aspartate Aminotransferase LevelsNeutral
Small
Lactobacillus acidophilus UALa01Unchanged Heat Shock Protein LevelsNeutral
Small

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