Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5.
- 2016-12
- Food Research International 90
- C. S. Moura
- P. Lollo
- P. Morato
- E. Esmerino
- L. P. Margalho
- V. A. Santos-Junior
- P. T. Coimbra
- L. Cappato
- M. C. Silva
- A. S. Garcia-Gomes
- D. Granato
- H. Bolini
- A. Sant’Ana
- A. Cruz
- J. Amaya-Farfan
- PubMed: 29195882
- DOI: 10.1016/j.foodres.2016.10.042
Study Design
- Type
- Clinical Trial
- Population
- Wistar rats
- Methods
- In vivo experiment with dietary intervention in rats
- Animal Study
Abstract
The viability and survival of Lactobacillus acidophilus La5 under in vitro simulated gastrointestinal in probiotic dairy dessert was assessed. In addition, the effects of regular consumption of the dessert (5g/day) on the lipid profile, immune system, and antioxidant/biochemical status of Wistar rats were also evaluated after 2weeks of treatment. Adequate counts of L. acidophilus La-5 were observed regards the viability and gastrointestinal conditions. The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum. Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p>0.05) after 15days of treatment. Overall, the probiotic dairy dessert may be a viable alternative to enhance the blood lipid profile and could be used to improve the antioxidant defenses.
Keywords: Antioxidant defense; Dairy dessert; Immune system; Probiotic bacteria.
Research Insights
The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum.
- Effect
- Beneficial
- Effect size
- Moderate
Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small
The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum.
- Effect
- Beneficial
- Effect size
- Moderate
The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum.
- Effect
- Beneficial
- Effect size
- Moderate
Aspartate amino transferase, alanine aminotransferase, total protein, albumin... were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small
Aspartate amino transferase, alanine aminotransferase, total protein... were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small
The probiotic dairy dessert was efficient in reducing the LDL-cholesterol.
- Effect
- Beneficial
- Effect size
- Moderate
The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum.
- Effect
- Beneficial
- Effect size
- Moderate
Aspartate amino transferase, alanine aminotransferase... were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small
Aspartate amino transferase... were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small
Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins... were not affected (p>0.05) after 15days of treatment.
- Effect
- Neutral
- Effect size
- Small