Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5.
- 2016-12
- Food Research International 90
- C. S. Moura
- P. Lollo
- P. Morato
- E. Esmerino
- L. P. Margalho
- V. A. Santos-Junior
- P. T. Coimbra
- L. Cappato
- M. C. Silva
- A. S. Garcia-Gomes
- D. Granato
- H. Bolini
- A. Sant’Ana
- A. Cruz
- J. Amaya-Farfan
- PubMed: 29195882
- DOI: 10.1016/j.foodres.2016.10.042
Abstract
The viability and survival of Lactobacillus acidophilus La5 under in vitro simulated gastrointestinal in probiotic dairy dessert was assessed. In addition, the effects of regular consumption of the dessert (5g/day) on the lipid profile, immune system, and antioxidant/biochemical status of Wistar rats were also evaluated after 2weeks of treatment. Adequate counts of L. acidophilus La-5 were observed regards the viability and gastrointestinal conditions. The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum. Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p>0.05) after 15days of treatment. Overall, the probiotic dairy dessert may be a viable alternative to enhance the blood lipid profile and could be used to improve the antioxidant defenses.
Keywords: Antioxidant defense; Dairy dessert; Immune system; Probiotic bacteria.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus acidophilus | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus acidophilus | Unchanged Biochemical Parameters | Neutral | Small |
| Lactobacillus acidophilus HA-122 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Maintained Blood-Cell Counts | Neutral | Small |
| Lactobacillus acidophilus HA-122 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus HA-122 | Stable Immune System Responses | Neutral | Small |
| Lactobacillus acidophilus L-92 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus L-92 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus acidophilus L-92 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus LA-02 | Enhanced Antioxidant Defense | Beneficial | Moderate |
| Lactobacillus acidophilus LA-02 | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus acidophilus LA1 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus LA1 | No Significant Changes in Immune Parameters | Neutral | Small |
| Lactobacillus acidophilus LA1 | No Significant Effect on Liver Enzymes | Neutral | Small |
| Lactobacillus acidophilus LA1 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus acidophilus LA1 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus LA1 | Unchanged Antioxidant Defenses | Neutral | Small |
| Lactobacillus acidophilus La-14 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus La-14 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus acidophilus La-14 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus LA-5 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus LA-5 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus acidophilus LA-5 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus LA85 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus LA85 | No Change in Immune System Response | Neutral | Small |
| Lactobacillus acidophilus LA85 | No Change in Liver Enzymes | Neutral | Small |
| Lactobacillus acidophilus LA85 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus acidophilus LA85 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus MAK32L61A | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus acidophilus MAK32L61A | Unchanged Biochemical Parameters | Neutral | Small |
| Lactobacillus acidophilus NCIMB 30333 | Improved Lipid Levels | Beneficial | Moderate |
| Lactobacillus acidophilus NCIMB 30333 | Unchanged Biochemical Parameters | Neutral | Small |
| Lactobacillus acidophilus R0418 | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Improved HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Improved LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus SD-5212 | Stable Blood Cell Counts | Neutral | Small |
| Lactobacillus acidophilus SD-5212 | Unchanged Liver Function Markers | Neutral | Small |
| Lactobacillus acidophilus UALa01 | Increased HDL Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Maintained Albumin Levels | Neutral | Small |
| Lactobacillus acidophilus UALa01 | Maintained Total Protein Levels | Neutral | Small |
| Lactobacillus acidophilus UALa01 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus acidophilus UALa01 | Stable Alanine Aminotransferase Levels | Neutral | Small |
| Lactobacillus acidophilus UALa01 | Stable Aspartate Aminotransferase Levels | Neutral | Small |
| Lactobacillus acidophilus UALa01 | Unchanged Heat Shock Protein Levels | Neutral | Small |