Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis.

2025-06-12
Frontiers in immunology 16
- Hongli Wang
- Min Chen
- Tengyue Wang
- Wenyu Cai
- Xuanlin Li
- Lin Huang
- Mingzhu Wang

PubMed: 40574848
DOI: 10.3389/fimmu.2025.1539997

Study Design

Type: Meta-Analysis
Sample size: n = 723
Population: 1,629,723 patients with atopic dermatitis and 15,106,889 control subjects
Methods: Systematic review and meta-analysis of cohort, case-control, and cross-sectional studies

Background

Atopic dermatitis (AD) is a common recurrent chronic inflammatory skin disease, and there is increasing evidence of a possible association between AD and autoimmune diseases.

Objectives

This study aimed to summarize existing epidemiological studies on the association between AD and autoimmune diseases and to perform a meta-analysis of combinable results.

Methods

We conducted a thorough search for cohort studies, case-control studies and cross-sectional studies across the PubMed, Cochrane Library, and Embase databases, from their inception to May 24, 2024, using medical subject headings and relevant keywords. All data were meticulously analyzed using Stata statistical software version 17.0. The protocol was registered on PROSPERO (CRD42024547282).

Result

A total of 26 cohort studies, comprising 1,629,723 patients with atopic dermatitis and 15,106,889 control subjects, were included in this meta-analysis. These studies were published between 2014 and 2024 and included 19 cohort studies, 2 case-control studies, and 5 cross-sectional studies. The current study demonstrated a significant association of atopic dermatitis with autoimmune diseases[HR 1.49, 95% CI (1.31-1.70); P<0.001], including celiac disease, systemic lupus erythematosus, Sjogren's syndrome, ankylosing spondylitis, alopecia areata, rheumatoid arthritis, vitiligo, thyroid dysfunction, ulcerative colitis.

Conclusion

The results of our study indicate a clear association between atopic dermatitis and autoimmune diseases, both in adults and children. Additionally, women were more likely to have autoimmune disease complications than men. However, due to the limited number of participants in our study, further research is needed to thoroughly investigate the relationship.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024547282.