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Abstract

This study enrolled 125 premenopausal women diagnosed with bacterial vaginosis (BV) by presence of vaginal irritation, discharge and 'fishy' odor, and Nugent criteria and detection of sialidase enzyme. The subjects were treated with oral metronidazole (500 mg) twice daily from days 1 to 7, and randomized to receive oral Lactobacillus rhamnosus GR-1 (1 x 10(9)) and Lactobacillus reuteri RC-14 (1 x 10(9)) or placebo twice daily from days 1 to 30. Primary outcome was cure of BV as determined by normal Nugent score, negative sialidase test and no symptoms or signs of BV at day 30. A total of 106 subjects returned for 30-day follow-up, of which 88% were cured in the antibiotic/probiotic group compared to 40% in the antibiotic/placebo group (p<0.001). Of the remaining subjects, 30% subjects in the placebo group and none in the probiotic group had BV, while 30% in the placebo and 12% in the probiotic group fell into the intermediate category based upon Nugent score, sialidase result and clinical findings. High counts of Lactobacillus sp. (>10(5) CFU/ml) were recovered from the vagina of 96% probiotic-treated subjects compared to 53% controls at day 30. In summary, this study showed efficacious use of lactobacilli and antibiotic in the eradication of BV in black African women.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteri RC-14Increased Cure Rate of Bacterial VaginosisBeneficial
Large
Lactobacillus reuteri RC-14Increased Vaginal Lactobacillus CountsBeneficial
Large
Lactobacillus rhamnosus GR-1Increased Cure Rate of Bacterial VaginosisBeneficial
Large
Lactobacillus rhamnosus GR-1Increased Vaginal Lactobacilli ColonizationBeneficial
Large
Lactobacillus rhamnosus LBV 96Increased Cure Rate of Bacterial VaginosisBeneficial
Large
Lactobacillus rhamnosus LBV 96Increased Vaginal Lactobacillus CountsBeneficial
Large
Lactobacillus rhamnosus LBV 96Reduced Nugent ScoreBeneficial
Large
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