Bacillus clausii for Gastrointestinal Disorders: A Narrative Literature Review.
- 2022-08-26
- Advances in therapy 39(11)
- PubMed: 36018495
- DOI: 10.1007/s12325-022-02285-0
Study Design
- Type
- Review
- Population
- children and adults
- Methods
- narrative literature review
The gut microbiota is intrinsically linked to human health; disturbances in microbial homeostasis are implicated in both intestinal and extraintestinal disorders. Probiotics are "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host," and many commercial preparations comprising a diverse range of species are available. While probiotics have been much researched, better understanding of the probiotic effects and applications of species such as Bacillus clausii is warranted. In this narrative literature review, we review the characteristics and mechanisms of action supporting B. clausii as a probiotic and discuss the evidence from clinical studies evaluating B. clausii probiotics for the management of a variety of gastrointestinal disorders and symptoms in children and adults. Finally, we highlight the challenges of future research and the need for more robust and diverse clinical evidence to guide physicians in the clinical application of probiotics for gastrointestinal disorders and other conditions.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Bacillus clausii SNZ-1971 | — | Improved Gastrointestinal Symptoms | Beneficial | Moderate | View sourceThis narrative literature review... discuss[es] the evidence from clinical studies evaluating B. clausii probiotics for the management of a variety of gastrointestinal disorders and symptoms in children and adults. |