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Bacillus coagulans and its applications in medicine.

  • 2019-07-10
  • Beneficial Microbes 10(6)
    • Y. Mu
    • Y. Cong

Abstract

Bacillus coagulans is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Additionally, toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity. This review summarises the latest advances associated with B. coagulans, from its biological features, probable action mechanisms, toxicity, and medical applications.

Keywords: Bacillus coagulans; medical application.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus coagulansNo Mutagenic EffectsNeutral
Large
Bacillus coagulansReduced Acute Diarrhea IncidenceBeneficial
Moderate
Bacillus coagulansReduced Antibiotic-Related DiarrheaBeneficial
Moderate
Bacillus coagulansReduced ConstipationBeneficial
Moderate
Bacillus coagulansReduced Symptoms of Irritable Bowel SyndromeBeneficial
Moderate
Bacillus coagulansReduced Ulcerative Colitis SymptomsBeneficial
Moderate
Bacillus coagulans ProDuraImproved Constipation ManagementBeneficial
Moderate
Bacillus coagulans ProDuraImproved Irritable Bowel Syndrome SymptomsBeneficial
Moderate
Bacillus coagulans ProDuraImproved Management of Acute DiarrhoeaBeneficial
Moderate
Bacillus coagulans ProDuraImproved Management of Antibiotic-Related DiarrheaBeneficial
Moderate
Bacillus coagulans ProDuraImproved Management of ColitisBeneficial
Moderate
Bacillus coagulans ProDuraNo Mutagenicity, Teratogenicity, or GenotoxicityNeutral
Large
Bacillus coagulans SC208Improved Intestinal FunctionBeneficial
Large
Bacillus coagulans SNZ-1969Improved Intestinal FunctionBeneficial
Large
Bacillus coagulans Unique IS-2Improved Irritable Bowel Syndrome SymptomsBeneficial
Moderate
Bacillus coagulans Unique IS-2Reduced Acute Diarrhea IncidenceBeneficial
Moderate
Bacillus coagulans Unique IS-2Reduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bacillus coagulans Unique IS-2Reduced Colitis SymptomsBeneficial
Moderate
Bacillus coagulans Unique IS-2Relieved ConstipationBeneficial
Moderate

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