Bacillus coagulans and its applications in medicine.
- 2019-07-10
- Beneficial Microbes 10(6)
- Y. Mu
- Y. Cong
- PubMed: 31203635
- DOI: 10.3920/BM2019.0016
Abstract
Bacillus coagulans is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Additionally, toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity. This review summarises the latest advances associated with B. coagulans, from its biological features, probable action mechanisms, toxicity, and medical applications.
Keywords: Bacillus coagulans; medical application.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bacillus coagulans | No Mutagenic Effects | Neutral | Large |
| Bacillus coagulans | Reduced Acute Diarrhea Incidence | Beneficial | Moderate |
| Bacillus coagulans | Reduced Antibiotic-Related Diarrhea | Beneficial | Moderate |
| Bacillus coagulans | Reduced Constipation | Beneficial | Moderate |
| Bacillus coagulans | Reduced Symptoms of Irritable Bowel Syndrome | Beneficial | Moderate |
| Bacillus coagulans | Reduced Ulcerative Colitis Symptoms | Beneficial | Moderate |
| Bacillus coagulans ProDura | Improved Constipation Management | Beneficial | Moderate |
| Bacillus coagulans ProDura | Improved Irritable Bowel Syndrome Symptoms | Beneficial | Moderate |
| Bacillus coagulans ProDura | Improved Management of Acute Diarrhoea | Beneficial | Moderate |
| Bacillus coagulans ProDura | Improved Management of Antibiotic-Related Diarrhea | Beneficial | Moderate |
| Bacillus coagulans ProDura | Improved Management of Colitis | Beneficial | Moderate |
| Bacillus coagulans ProDura | No Mutagenicity, Teratogenicity, or Genotoxicity | Neutral | Large |
| Bacillus coagulans SC208 | Improved Intestinal Function | Beneficial | Large |
| Bacillus coagulans SNZ-1969 | Improved Intestinal Function | Beneficial | Large |
| Bacillus coagulans Unique IS-2 | Improved Irritable Bowel Syndrome Symptoms | Beneficial | Moderate |
| Bacillus coagulans Unique IS-2 | Reduced Acute Diarrhea Incidence | Beneficial | Moderate |
| Bacillus coagulans Unique IS-2 | Reduced Antibiotic-Associated Diarrhea | Beneficial | Moderate |
| Bacillus coagulans Unique IS-2 | Reduced Colitis Symptoms | Beneficial | Moderate |
| Bacillus coagulans Unique IS-2 | Relieved Constipation | Beneficial | Moderate |