Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins.
- 2019-11
- Food Research International 125
- M. Anaya-Loyola
- J. A. Enciso-Moreno
- J. López-Ramos
- G. García-Marín
- María Y Orozco Álvarez
- Ana M Vega-García
- J. Mosqueda
- D. García-Gutiérrez
- D. Keller
- I. Pérez-Ramírez
- PubMed: 31554075
- DOI: 10.1016/J.FOODRES.2019.108567
Abstract
This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC30®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6-8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.
Keywords: Bacillus coagulans GBI-30; GanedenBC(30)®; Gastrointestinal; Immune system; Probiotic; Upper respiratory.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bacillus coagulans | Altered Serum Immune Protein Levels | Beneficial | Large |
| Bacillus coagulans | Reduced Duration of Upper Respiratory Tract Infection Symptoms | Beneficial | Moderate |
| Bacillus coagulans | Reduced Flatulence Incidence | Beneficial | Moderate |
| Bacillus coagulans | Reduced Incidence of Upper Respiratory Tract Infection Symptoms | Beneficial | Large |
| Bacillus coagulans GBI-30, 6086 | Increased Immune Marker Levels | Beneficial | Moderate |
| Bacillus coagulans GBI-30, 6086 | Reduced Duration of Upper Respiratory Tract Infection Symptoms | Beneficial | Moderate |
| Bacillus coagulans GBI-30, 6086 | Reduced Flatulence | Beneficial | Moderate |
| Bacillus coagulans GBI-30, 6086 | Reduced Incidence of Upper Respiratory Tract Infection Symptoms | Beneficial | Large |
| Bacillus coagulans SC208 | Reduced Duration of URTI-Associated Symptoms | Beneficial | Moderate |
| Bacillus coagulans SC208 | Reduced Incidence of Gastrointestinal Tract Infection Symptoms | Beneficial | Moderate |