Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis: A Cohort Study
- 2012
- Infectious Diseases in Obstetrics and Gynecology 2012
- C. Mitchell
- L. Manhart
- Kathy Thomas
- T. Fiedler
- D. Fredricks
- J. Marrazzo
- PubMed: 22693410
- DOI: 10.1155/2012/706540
Abstract
Objective: Evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis (BV).
Methods: Vaginal fluid specimens from women with BV underwent qPCR for Lactobacillus crispatus, L. jensenii, and L. iners pre- and posttreatment.
Results: Few women with BV were colonized with L. crispatus (4/44, 9%) or L. jensenii (1/44, 2%), though all had L. iners. One month posttreatment 12/44 (27%) had L. crispatus, 12/44 (27%) L. jensenii, and 43/44 (98%) L. iners. Presence of L. jensenii posttreatment was associated with cure (Risk Ratio (RR) 1.67; 95% CI 1.09-2.56); L. crispatus showed a similar trend (RR 1.41; 95% CI 0.89-2.24, P = 0.14). Receptive oral sex was associated with 2.2-log(10) lower concentration of L. crispatus (95% CI -4.38, -.02), and digital-vaginal sex with 2.6-log(10) lower concentration (95% CI -4.87, -.33).
Conclusion: One month after BV treatment, few women established colonization with L. crispatus or L. jensenii. Few behaviors were associated with colonization.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus jensenii LBV 116 | Increased Cure Rate of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus jensenii LJe52 | Improved Vaginal Health | Beneficial | Moderate |
| Lactobacillus jensenii VPro 32 | Colonization with Lactobacillus jensenii Post-Treatment | Beneficial | Moderate |