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Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis: A Cohort Study

  • 2012
  • Infectious Diseases in Obstetrics and Gynecology 2012
    • C. Mitchell
    • L. Manhart
    • Kathy Thomas
    • T. Fiedler
    • D. Fredricks
    • J. Marrazzo


Objective: Evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis (BV).

Methods: Vaginal fluid specimens from women with BV underwent qPCR for Lactobacillus crispatus, L. jensenii, and L. iners pre- and posttreatment.

Results: Few women with BV were colonized with L. crispatus (4/44, 9%) or L. jensenii (1/44, 2%), though all had L. iners. One month posttreatment 12/44 (27%) had L. crispatus, 12/44 (27%) L. jensenii, and 43/44 (98%) L. iners. Presence of L. jensenii posttreatment was associated with cure (Risk Ratio (RR) 1.67; 95% CI 1.09-2.56); L. crispatus showed a similar trend (RR 1.41; 95% CI 0.89-2.24, P = 0.14). Receptive oral sex was associated with 2.2-log(10) lower concentration of L. crispatus (95% CI -4.38, -.02), and digital-vaginal sex with 2.6-log(10) lower concentration (95% CI -4.87, -.33).

Conclusion: One month after BV treatment, few women established colonization with L. crispatus or L. jensenii. Few behaviors were associated with colonization.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus jensenii LBV 116Increased Cure Rate of Bacterial VaginosisBeneficial
Lactobacillus jensenii LJe52Improved Vaginal HealthBeneficial
Lactobacillus jensenii VPro 32Colonization with Lactobacillus jensenii Post-TreatmentBeneficial

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