Skip to main content

Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice.

  • 2005-02
  • FEMS Immunology & Medical Microbiology 43(2)
    • I. Castagliuolo
    • F. Galeazzi
    • S. Ferrari
    • M. Elli
    • P. Brun
    • A. Cavaggioni
    • D. Tormen
    • G. Sturniolo
    • L. Morelli
    • G. Palù

Abstract

We tested the therapeutic relevance of auto aggregation in lactobacilli by comparing the effect on DSS induced colitis of viable Lactobacillus crispatus M247, isolated from healthy humans, to L. crispatus MU5, an isogenic spontaneous mutants of M247, the latter lacking the auto aggregation phenotype which allows the adhesion to human mucus. Aggregating L. crispatus M247, but not the non-aggregating MU5, was retrievable from mice feces and adherent to the colonic mucosa. Daily administration of L. crispatus M247, but not heat killed L. crispatus M247 or aggregation deficient L. crispatus MU5, dose-dependently reduced the severity of DSS colitis. Indeed, L. crispatus MU5 administered in a 30% sucrose solution, known to restore the aggregation phenotype, had a protective effect comparable to mice receiving L. crispatus M247. These results indicate that a surface-mediated property such as aggregation may play a pivotal role in the protective effects obtained by dietary supplementation with L. crispatus M247 during colitis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus crispatus LV5 88Increased Colonic Mucosa AdhesionBeneficial
Large
Lactobacillus crispatus LV5 88Reduced Severity of DSS-Induced ColitisBeneficial
Large
Lactobacillus crispatus LV5 88Restored Protective Effect in ColitisBeneficial
Large
Lactobacillus crispatus UALcr-35Enhanced Colonic Mucosa AdhesionBeneficial
Moderate
Lactobacillus crispatus UALcr-35Reduced Colitis SeverityBeneficial
Large
Lactobacillus crispatus UALcr-35Restored Aggregation Phenotype and Protective Effect on ColitisBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.