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Abstract

Objective: Human studies have shown the beneficial effects of probiotic microorganisms on the parameters of metabolic syndrome (MetS) and other cardiovascular risks, but to our knowledge the effect of Bifidobacterium lactis has not yet been reported. The aim of this study was to evaluate the effect of consumption of milk containing the probiotic B. lactis HN019 on the classical parameters of MetS and other related cardiovascular risk factors.

Methods: Fifty-one patients with MetS were selected and divided into a control group (n = 25) and a probiotic group (n = 26). The probiotic group consumed fermented milk with probiotics over the course of 45 d. The effects of B. lactis on lipid profile, glucose metabolism, and proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) were assessed in blood samples of the individuals at the baseline and after 45 d.

Results: Daily ingestion of 80 mL fermented milk with 2.72 × 10(10) colony-forming units of B. lactis HN019 showed significant reduction in body mass index (P = 0.017), total cholesterol (P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and control group values. Furthermore, a significant decrease in tumor necrosis factor-α (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was observed.

Conclusion: These data showed potential effects of B. lactis HN019 in reducing obesity, blood lipids, and some inflammatory markers, which may reduce cardiovascular risk in patients with MetS.

Keywords: Bifidobacterium lactis; Cardiovascular risk factors; Cytokines; Metabolic syndrome; Probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalis subsp. lactis HN019Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactisReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactisReduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactisReduced LDL CholesterolBeneficial
Large
Bifidobacterium lactisReduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactisReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis B420Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis B420Reduced Low-Density Lipoprotein CholesterolBeneficial
Moderate
Bifidobacterium lactis B420Reduced Proinflammatory CytokinesBeneficial
Moderate
Bifidobacterium lactis B420Reduced Total CholesterolBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Low-Density Lipoprotein CholesterolBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Total CholesterolBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Tumor Necrosis Factor-α LevelsBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis HN019Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis HN019Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis HN019Reduced LDL CholesterolBeneficial
Large
Bifidobacterium lactis HN019Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis HN019Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis/longumReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis/longumReduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis/longumReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis/longumReduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis/longumReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced LDL CholesterolBeneficial
Large
Bifidobacterium lactis R101-8Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Total Cholesterol LevelsBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Interleukin-6 LevelsBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Total CholesterolBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Tumor Necrosis Factor-α (TNF-α)Beneficial
Small

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