Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.
- 2016-06
- Nutrition 32(6)
- L. J. Bernini
- A. Simão
- D. Alfieri
- M. A. Lozovoy
- Naiara Lourenço Mari
- C. H. B. de Souza
- I. Dichi
- G. N. Costa
- PubMed: 27126957
- DOI: 10.1016/j.nut.2015.11.001
Abstract
Objective: Human studies have shown the beneficial effects of probiotic microorganisms on the parameters of metabolic syndrome (MetS) and other cardiovascular risks, but to our knowledge the effect of Bifidobacterium lactis has not yet been reported. The aim of this study was to evaluate the effect of consumption of milk containing the probiotic B. lactis HN019 on the classical parameters of MetS and other related cardiovascular risk factors.
Methods: Fifty-one patients with MetS were selected and divided into a control group (n = 25) and a probiotic group (n = 26). The probiotic group consumed fermented milk with probiotics over the course of 45 d. The effects of B. lactis on lipid profile, glucose metabolism, and proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) were assessed in blood samples of the individuals at the baseline and after 45 d.
Results: Daily ingestion of 80 mL fermented milk with 2.72 × 10(10) colony-forming units of B. lactis HN019 showed significant reduction in body mass index (P = 0.017), total cholesterol (P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and control group values. Furthermore, a significant decrease in tumor necrosis factor-α (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was observed.
Conclusion: These data showed potential effects of B. lactis HN019 in reducing obesity, blood lipids, and some inflammatory markers, which may reduce cardiovascular risk in patients with MetS.
Keywords: Bifidobacterium lactis; Cardiovascular risk factors; Cytokines; Metabolic syndrome; Probiotic.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced LDL Cholesterol | Beneficial | Large |
| Bifidobacterium lactis | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Low-Density Lipoprotein Cholesterol | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Proinflammatory Cytokines | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Total Cholesterol | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Low-Density Lipoprotein Cholesterol | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Total Cholesterol | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Tumor Necrosis Factor-α Levels | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Reduced LDL Cholesterol | Beneficial | Large |
| Bifidobacterium lactis HN019 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced LDL Cholesterol | Beneficial | Large |
| Bifidobacterium lactis R101-8 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Total Cholesterol | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Tumor Necrosis Factor-α (TNF-α) | Beneficial | Small |