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Beta-alanine fails to improve on 5000 m running time despite increasing PAT1 expression in long-distance runners.

  • 2021-11
  • The Journal of sports medicine and physical fitness 61(12)
    • Gabriel S Franco
    • Natália Y Noronha
    • Bruno A Oliveira
    • Flávia C Ferreira
    • Ana P Pinto
    • Camila F Brandao
    • Marcelo Papoti
    • Carla B Nonino

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 16
Population
16 long-distance runners (37±8 years)
Methods
Double-blind, randomized study, 4.8 g/day beta-alanine or placebo for four weeks
Blinding
Double-blind
Duration
four weeks

Background

Beta-alanine has become a dietary supplement widely used by athletes due to its ergogenic effect. However, there is still no consensus on the performance benefit of beta-alanine on exercise lasting longer than ten minutes. The present study aimed to evaluate the effect of beta-alanine supplementation on running performance and the expression of TauT and PAT1.

Methods

This double-blind, randomized study enrolled 16 long-distance runners (37±8 years) who were randomly allocated to two groups: placebo (PLA) and beta-alanine (BA) (4.8 g/day 1) for four weeks. Maximal oxygen consumption, anthropometry, body composition, and food intake were determined. Before and after the intervention, the athletes undertook a 5000 m running time trial. Venous blood (TauT and PAT1 expressions) and ear lobe capillary blood (lactate) collected before and after exercise. Between tests, we monitored the training variables.

Results

The results were analyzed by t-tests and an ANOVA of repeated measures, with Sidak's post hoc (P<0.05). PLA exhibited lower body fat than BA (8.7±2.2 vs. 11.5±2.8%, P=0.04). After supplementation, there was an increase in PAT1 expression in BA when compared to PLA (1.17±0.47 vs. 0.77±0.18, P=0.04). No significant differences were shown for the 5000 m running time in PLA (PRE: 1128±72; POST: 1123±72s) and BA (PRE: 1107±95; POST: 1093±86s).

Conclusions

Although beta-alanine supplementation increased PAT1 expression, there was no statistically significant improvement in 5000 m running performance. However, individual responses should be considered as the BA showed a higher delta than the PLA.

Research Insights

  • Beta-Alanine→Improved 5000 m Running Time

    No significant differences were shown for the 5000 m running time in PLA (PRE: 1128±72; POST: 1123±72s) and BA (PRE: 1107±95; POST: 1093±86s).

    Effect
    Neutral
    Effect size
    Small
    Dose
    4.8 g/day
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